P4394

cis-Diammineplatinum(II) dichloride

≥99.99% (trace metal analysis), crystalline, macrophage activator

• Sinonimo/i: cis-Dichlorodiammine platinum(II), cis-Platinum(II) diammine dichloride, Cisplatin
• Formula condensata: Pt(NH₃)₂Cl₂
• Numero CAS: 15663-27-1
• Peso molecolare: 300.05
• NACRES: NA.77
• PubChem Substance ID: 24278632
• UNSPSC Code: 12352200
• EC Number: 239-733-8
• MDL number: MFCD00011623
• Form: crystalline

Proprietà

• Nome del prodotto: cis-Diammineplatinum(II) dichloride, crystalline
• form: crystalline
• Quality Segment: 200
• color: yellow
• mp: 270 °C (lit.)
• antibiotic activity spectrum: neoplastics
• mode of action: DNA synthesis | interferes
• originator: Corden
• SMILES string: N.N.Cl[Pt]Cl
• InChI: 1S/2ClH.2H3N.Pt/h2*1H;2*1H3;/q;;;;+2/p-2
• InChI key: LXZZYRPGZAFOLE-UHFFFAOYSA-L

Descrizione

Application

cis-Diammineplatinum(II) dichloride has been used:

• in cell viability measurement in cochlear explants
• in the inhibition of cell proliferation and chemosensitivity in ovarian cancer cell lines
• in MTT [3-(4,5-Dimethylthiazol-2-yl)-2,5-Diphenyltetrazolium Bromide] cell viability assay in oral squamous cell carcinoma

Biochem/physiol Actions

Potent chemoimmunotherapeutic drug; stimulates the immune responses by activating macrophages and other cells of the immune system. Cisplatin-treated macrophages show increased antigen presentation function in vitro. Treatment increased cellular NF-κB content and translocation in macrophages. Cisplatin effects are regulated by kinases, phosphatases, and Ca²⁺/calmodulin. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand crosslinks.

Potent platinum-based antineoplastic agent. Forms cytotoxic adducts with the DNA dinucleotide d(pGpG), inducing intrastrand cross-links.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

This compound was developed by Corden. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Preparation Note

This product is to be stored in room temperature. Keep the product tightly closed in a well-ventilated place. Dry. Please view the Safety Data Sheet for more information.

Informazioni sulla sicurezza

• pictograms: GHS06,GHS08
• signalword: Danger
• pcodes: P202 - P261 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• target_organs: Respiratory system
• Classe di stoccaggio: 6.1B - Non-combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• hcodes: H300,H315,H317,H319,H334,H335,H340,H350,H360FD
• Hazard Classifications: Acute Tox. 2 Oral - Carc. 1B - Eye Irrit. 2 - Muta. 1B - Repr. 1B - Resp. Sens. 1 - Skin Irrit. 2 - Skin Sens. 1 - STOT SE 3