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P0098

Sigma-Aldrich

Pediocin from Pediococcus acidilactici

≥95% (HPLC), buffered aqueous solution

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About This Item

Numero CAS:
Codice UNSPSC:
51102829
NACRES:
NA.85

Livello qualitativo

Saggio

≥95% (HPLC)

Forma fisica

buffered aqueous solution

Concentrazione

0.1 mg/mL in 0.1 M sodium acetate pH 5.0

Spettro attività antibiotica

Gram-positive bacteria

Modalità d’azione

cell membrane | interferes

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

Descrizione generale

Chemical structure: peptide

Applicazioni

Pediocins have molecular masses of about 2,700 to 4,000 Da. They are potential food biopreservatives used to control food-borne pathogens and spoilage.

Azioni biochim/fisiol

Pediocins are class IIa bacteriocins that are produced by Pediococcus acidilactici. They are cationic peptides with molecular masses of about 2,700 to 4,000 Da, that show strong activity against pathogenic bacteria such as Listeria monocytogenes, Clostridicum perfringes, Enterococcus faecalis, and Staphylococcus aureus.4 This antimicrobial action of pediocins is based on interactions with the cytoplasmic membrane, resulting in pore formation and cell death. These interactions also cause a change in membrane potentials, which leads to a loss of the proton motive force and an efflux of intracellular ions, ultimately causing cell death. They have been shown to inhibit Listeria monocytogenes.

Altre note

50ug
Keep container tightly closed in a dry and well-ventilated place.

Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


Certificati d'analisi (COA)

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M J Pucci et al.
Applied and environmental microbiology, 54(10), 2349-2353 (1988-10-01)
The bacteriocin produced by Pediococcus acidilactici PAC 1.0, previously designated PA-1 bacteriocin, was found to be inhibitory and bactericidal for Listeria monocytogenes. A dried powder prepared from PAC 1.0 culture supernatant fortified with 10% milk powder was found to contain
A K Bhunia
Applied and environmental microbiology, 60(8), 2692-2696 (1994-08-01)
Monoclonal antibody (MAb) R2-AR against pediocin RS2 was developed. Mice were immunized for 12 weeks with pediocin RS2 conjugated to a polyacrylamide gel. Two hybridoma fusions yielded an MAb that in Western blots (immunoblots) reacted only with pediocins RS2 and
Pamela Oliveira de Souza de Azevedo et al.
Scientific reports, 10(1), 12291-12291 (2020-07-25)
Pediococcus pentosaceus LBM 18 has shown potential as producer of an antibacterial and antifungal bacteriocin-like inhibitory substance (BLIS). BLIS inhibited the growth of spoilage bacteria belonging to Lactobacillus, Enterococcus and Listeria genera with higher activity than Nisaplin used as control.

Articoli

Ribosomally synthesized antimicrobial peptides are a promising focus in antibiotic research amidst bacterial resistance and emerging infectious diseases.

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