O8890

OU749

≥98% (HPLC)

• Sinonimo/i: N-[5-(4-Methoxybenzyl)-1,3,4-thiadiazol-2-yl]benzenesulfonamide
• Formula empirica (notazione di Hill): C₁₆H₁₅N₃O₃S₂
• Numero CAS: 519170-13-9
• Peso molecolare: 361.44
• Numero MDL: MFCD03351667
• Codice UNSPSC: 12352200
• ID PubChem: 329818930

Proprietà

• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Colore: white to off-white
• Solubilità: DMSO: >20 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: COc1ccc(Cc2nnc(NS(=O)(=O)c3ccccc3)s2)cc1
• InChI: 1S/C16H15N3O3S2/c1-22-13-9-7-12(8-10-13)11-15-17-18-16(23-15)19-24(20,21)14-5-3-2-4-6-14/h2-10H,11H2,1H3,(H,18,19); QCXWBMZVLJCKHF-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

Gamma-glutamyl transpeptidase (GGT; aka gamma-glutamyl transferase) cleaves the gamma-glutamyl bond of glutathione, making extracellular glutathione available for intracellular use. Elevated intracellular glutathione contributes to resistance of tumors to chemotherapy and radiation. GGT is a therapeutic target for treatment-resistance cancers, as treatment with GGT inhibitors prior to chemotherapy or radiation could sensitize GGT-positive tumors to treatment by decreasing glutathione levels. Previously, all GGT inhibitors have been glutamine analogues, which are competitive for the gamma-glutamyl site. Due to high toxicity, these compounds cannot be used in the clinic. OU749 is the first non-glutamine GGT inhibitor. It is also non-competitive for the gamma-glutamyl site. OU749 inhibits human GGT in an enzyme assay and is much less toxic than other GGT inhibitors, including azaserine (glutamine analogue, Sigma catalog).

Informazioni sulla sicurezza

• Pittogrammi: GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302
• Classi di pericolo: Acute Tox. 4 Oral
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable