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Key Documents

N5912

Sigma-Aldrich

Anti-NORE1 (RASSF5) antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-RAPL, Anti-Ras Association (RalGDS/AF-6) Domain Family 5

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About This Item

Numero MDL:
Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

rabbit

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

Reattività contro le specie

mouse, rat, human

tecniche

western blot: 1:500-1:1,000

N° accesso UniProt

Condizioni di spedizione

dry ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... RASSF5(83593)
mouse ... Rassf5(54354)
rat ... Rassf5(54355)

Descrizione generale

Ras association domain family member 5 (RASSF5) is also known as novel Ras effector- 1 (NORE-1). It exists in three isoforms and the gene encoding it is located on human chromosome 1q32.1.

Immunogeno

peptide corresponding to the NORE1 protein (amino acids 313-329). This sequence is located in the RA domain of NORE1 and is 100% conserved between human, mouse, rat, and hamster.

Azioni biochim/fisiol

Ras association domain family member 5 (RASSF5) is a tumor suppressor protein. It interacts with kinases like mammalian sterile 20-like kinase 1/2 (MST1/2). RASSF5 is involved in the regulation of cell cycle and apoptosis.

Stato fisico

Solution of 1 mg/mL in phosphate buffered saline containing 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable


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Xu-Hui Zhou et al.
Oncology reports, 32(4), 1505-1512 (2014-08-12)
Ras association (RalGDS/AF-6) domain family member RASSF5 has been implicated in a variety of key biological processes, including cell proliferation, cell cycle regulation and apoptosis. It is believed to play an important role in tumorigenesis as a tumor suppressor in
Katherine K Slemmons et al.
Cancer research, 80(14), 3046-3056 (2020-05-02)
Rhabdomyosarcoma is the most common childhood soft-tissue sarcoma, yet patients with metastatic or recurrent disease continue to do poorly, indicating a need for new treatments. The SRC family tyrosine kinase YES1 is upregulated in rhabdomyosarcoma and is necessary for growth
Xiaoli Liu et al.
Frontiers in oncology, 10, 600927-600927 (2021-01-26)
The principal issue derived from thyroid cancer is its high propensity to metastasize to the lymph node. Aberrant exprssion of long non-coding RNAs have been extensively reported to be significantly correlated with lymphatic metastasis of thyroid cancer. However, the clinical
Hye Jin Kim et al.
Acta crystallographica. Section F, Structural biology and crystallization communications, 68(Pt 7), 813-815 (2012-07-04)
NORE1 is an important tumour suppressor in human cancers that interacts with the pro-apoptotic protein kinase MST1/2 through SARAH domains. The SARAH domain (residues 366-413) of human NORE1 was expressed in Escherichia coli, purified and crystallized using the hanging-drop vapour-diffusion
Wei Guo et al.
Clinical & experimental metastasis, 32(1), 83-98 (2015-01-13)
As a result of alternative splicing and differential promoter usage, RASSF5 exists in at least three isoforms (RASSF5A-RASSF5C), which may play different roles in tumorigenesis. The present study was to detect the role of RASSF5A, B and C in esophageal

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