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N3136

Naltrexone hydrochloride

≥99% (HPLC), powder, opioid receptor antagonist

Sinonimo/i:

Naltrexone HCl

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100 mg
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CHF 95.00
250 mg
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CHF 190.00
1 g
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CHF 573.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C20H23NO4 · HCl
Numero CAS:
16676-29-2
Peso molecolare:
377.86
NACRES:
NA.77
PubChem Substance ID:
24278051
UNSPSC Code:
12352200
EC Number:
240-723-0
MDL number:
MFCD00069324
Beilstein/REAXYS Number:
3580333
Form:
powder

CHF 95.00

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Nome del prodotto

Naltrexone hydrochloride,

form

powder

Quality Segment

100

originator

Novartis

storage temp.

2-8°C

SMILES string

Cl.Oc1ccc2C[C@H]3N(CC[C@@]45[C@@H](Oc1c24)C(=O)CC[C@@]35O)CC6CC6

InChI

1S/C20H23NO4.ClH/c22-13-4-3-12-9-15-20(24)6-5-14(23)18-19(20,16(12)17(13)25-18)7-8-21(15)10-11-1-2-11;/h3-4,11,15,18,22,24H,1-2,5-10H2;1H/t15-,18+,19+,20-;/m1./s1

InChI key

RHBRMCOKKKZVRY-ITLPAZOVSA-N

Gene Information

human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)

Application

Naltrexone hydrochloride has been used:
  • as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model
  • to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model
  • in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22

Biochem/physiol Actions

Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.

Features and Benefits

This compound is featured on the Opioid Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Novartis. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Questo articolo
SML0277681625178281
Naltrexone hydrochloride

Sigma-Aldrich

N3136

Naltrexone hydrochloride

Methylnaltrexone bromide ≥97% (HPLC)

Sigma-Aldrich

SML0277

Methylnaltrexone bromide

W-5, Hydrochloride A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 230 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM).

Sigma-Aldrich

681625

W-5, Hydrochloride

p-APMSF, Hydrochloride Alternative to DFP and PMSF.

Sigma-Aldrich

178281

p-APMSF, Hydrochloride

description

-

description

≥97% (HPLC)

description

A cell-permeable and reversible calmodulin antagonist that inhibits myosin light chain kinase (IC50 = 230 µM) and Ca2+-calmodulin-dependent phosphodiesterase (IC50 = 240 µM).

description

Alternative to DFP and PMSF.

form

powder

form

powder

form

crystalline solid

form

solid

Quality Level

100

Quality Level

100

Quality Level

100

Quality Level

100

storage temp.

2-8°C

storage temp.

−20°C

storage temp.

2-8°C

storage temp.

2-8°C

originator

Novartis

originator

-

originator

-

originator

-

Gene Information

human ... OPRD1(4985), OPRK1(4986), OPRM1(4988), OPRS1(10280)

Gene Information

human ... OPRM1(4988)

Gene Information

-

Gene Information

-

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pictograms

Exclamation mark
GHS07

signalword

Warning

hcodes

H302

Hazard Classifications

Acute Tox. 4 Oral

Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

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