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N0267

Sigma-Aldrich

(±)-Nicotine

≥99% (TLC), liquid

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About This Item

Formula empirica (notazione di Hill):
C10H14N2
Numero CAS:
22083-74-5
Peso molecolare:
162.23
Beilstein:
82108
Numero MDL:
MFCD00065370
Codice UNSPSC:
12352210
eCl@ss:
39151701
ID PubChem:
24897418
NACRES:
NA.77

Livello qualitativo

200

Saggio

≥99% (TLC)

Forma fisica

liquid

Attività ottica

[α]25/D 0°(lit.)

Colore

yellow

Solubilità

ethanol: 50 mg/mL

Densità

1.02 g/mL at 25 °C (lit.)

Stringa SMILE

CN1CCCC1c2cccnc2

InChI

1S/C10H14N2/c1-12-7-3-5-10(12)9-4-2-6-11-8-9/h2,4,6,8,10H,3,5,7H2,1H3
SNICXCGAKADSCV-UHFFFAOYSA-N

Informazioni sul gene

human ... CHRNA2(1135) , CHRNA3(1136) , CHRNA4(1137)
rat ... Chrna3(25101) , Chrna4(25590) , Chrna7(25302)

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Applicazioni

(±)-Nicotine has been used:
  • as a supplement of high-glucose Dulbecco′s modified Eagle′s medium, to test its effect on mesenchymal stem cells
  • as a standard for the determination of nicotine concentration using phase high-pressure liquid chromatography
  • as a test compound to study its effects on fibril formation

Azioni biochim/fisiol

(±)-Nicotine is a tertiary amine compound that is predominantly present in tobacco. It binds to the nicotinic cholinergic receptors of the brain, autonomic ganglia and neuromuscular junction. Nicotine allosterically regulates a number of biological events such as production of growth hormone, dopamine, adrenocorticotropic hormone and prolactin. Nicotine absorption across biological membranes is pH sensitive, which alters its ionization state. Absorption of nicotine is shown to be higher at alkaline pH, when it remains unionized. Nicotine metabolism occurs extensively in the liver and it can cross placenta.
Prototype nicotinic acetylcholine receptor agonist.

Avvertenze

Danger

Indicazioni di pericolo

H300 + H310 + H330,H315,H318,H411

Classi di pericolo

Acute Tox. 2 Dermal - Acute Tox. 2 Inhalation - Acute Tox. 2 Oral - Aquatic Chronic 2 - Eye Dam. 1 - Skin Irrit. 2

Codice della classe di stoccaggio

6.1A - Combustible acute toxic Cat. 1 and 2 / very toxic hazardous materials

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

213.8 °F - closed cup

Punto d’infiammabilità (°C)

101 °C - closed cup

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type ABEK (EN14387) respirator filter

Certificati d'analisi (COA)

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