M9948

Mirin

≥98% (HPLC), powder

• Sinonimo/i: 5-(4-Hydroxybenzylidene)-2-iminothiazolidin-4-one
• Formula empirica (notazione di Hill): C₁₀H₈N₂O₂S
• Numero CAS: 299953-00-7
• Peso molecolare: 220.25
• Numero MDL: MFCD05885480
• Codice UNSPSC: 12352200
• ID PubChem: 329818100
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Forma fisica: powder
• Condizioni di stoccaggio: desiccated
• Colore: red to orange
• Solubilità: DMSO: >10 mg/mL
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: NC1=NC(=O)C(\S1)=C\c2ccc(O)cc2
• InChI: 1S/C10H8N2O2S/c11-10-12-9(14)8(15-10)5-6-1-3-7(13)4-2-6/h1-5,13H,(H2,11,12,14)/b8-5-; YBHQCJILTOVLHD-YVMONPNESA-N
• Informazioni sul gene: human ... MRE11A(4361)

Descrizione

Applicazioni

Mirin has been used:

• as a small molecule inhibitor of meiotic recombination 11 (MRE11), in the pre-treatment of HCT116 wildtype cells before irradiation
• as Mre11 inhibitior in BSC-1 cells infected with simian virus 40
• in the pre-treatment of W12E cells for quantification of human papilloma virus (HPV) episome levels and to potentiate the effect of polyamide-25 (PA-25)

Azioni biochim/fisiol

Mirin causes cell cycle arrest at G1 phase. Mirin sensitizes virus to antiviral polyamides (AVP). In human papilloma virus (HPV) episomes, mirin promotes damage by forming double stranded DNA breaks. It aids in reducing the inhibitory concentration (IC50s) of AVP.

Mirin is an inhibitor of the Mre11-Rad50-Nbs1 complex. It disrupts nuclease activity of Mre11 and thus, the ability to repair DNA double strand breaks.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable