L9783

Leupeptin hydrochloride

powder, ≥90% (HPLC)

• Sinonimo/i: Acetyl-Leu-Leu-Arg-al hydrochloride
• Formula empirica (notazione di Hill): C₂₀H₃₈N₆O₄ · HCl
• Numero CAS: 24125-16-4
• Peso molecolare: 463.01
• UNSPSC Code: 12352202
• PubChem Substance ID: 24896529
• NACRES: NA.77
• MDL number: MFCD00133457

Proprietà

• Nome del prodotto: Leupeptin hydrochloride, microbial, ≥90% (HPLC)
• biological source: microbial
• Quality Segment: 200
• assay: ≥90% (HPLC)
• form: powder
• input: general use sample(s)
• solubility: water: 50 mg/mL, clear, colorless
• storage temp.: −20°C
• SMILES string: Cl.CC(C)CC(NC(C)=O)C(=O)NC(CC(C)C)C(=O)NC(CCCNC(N)=N)C=O
• InChI: 1S/C20H38N6O4.ClH/c1-12(2)9-16(24-14(5)28)19(30)26-17(10-13(3)4)18(29)25-15(11-27)7-6-8-23-20(21)22;/h11-13,15-17H,6-10H2,1-5H3,(H,24,28)(H,25,29)(H,26,30)(H4,21,22,23);1H
• InChI key: OQQYPQNFLLAILR-UHFFFAOYSA-N

Descrizione

Biochem/physiol Actions

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM.

Inhibitor of serine and cysteine proteases. Inhibits plasmin, trypsin, papain, calpain, and cathepsin B. Does not inhibit pepsin, cathepsins A and D, thrombin, or α-chymotrypsin. Effective concentration 10-100 μM. There have been numerous studies using leupeptin to protect against hearing loss caused by acoustic overstimulation or the ototoxic antibiotic gentamicin. (Loss of cochlear hair cells is believed to be mediated by calpain.)

Analysis Note

Leupeptin gives multiple peaks on HPLC because of the formation of tautomeric isomers in solution. Majority of contaminating peptide is racemized leupeptin.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)