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L5386

Sigma-Aldrich

[des-Gly10, D-Trp6]-LH-RH ethylamide

≥97% (HPLC)

Sinonimo/i:

Deslorelin

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About This Item

Formula empirica (notazione di Hill):
C64H83N17O12
Numero CAS:
57773-65-6
Peso molecolare:
1282.45
Numero MDL:
MFCD00167401
Codice UNSPSC:
12352200
ID PubChem:
329817623

Saggio

≥97% (HPLC)

N° accesso UniProt

P55248
P01148
P07490
P13562
P30968
P30969
Q01776

Temperatura di conservazione

−20°C

Stringa SMILE

CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CO)NC(=O)[C@H](Cc5c[nH]c6ccccc56)NC(=O)[C@H](Cc7c[nH]cn7)NC(=O)[C@@H]8CCC(=O)N8

InChI

1S/C64H83N17O12/c1-4-68-62(92)53-16-10-24-81(53)63(93)46(15-9-23-69-64(65)66)74-56(86)47(25-35(2)3)75-58(88)49(27-37-30-70-43-13-7-5-11-41(37)43)77-57(87)48(26-36-17-19-40(83)20-18-36)76-61(91)52(33-82)80-59(89)50(28-38-31-71-44-14-8-6-12-42(38)44)78-60(90)51(29-39-32-67-34-72-39)79-55(85)45-21-22-54(84)73-45/h5-8,11-14,17-20,30-32,34-35,45-53,70-71,82-83H,4,9-10,15-16,21-29,33H2,1-3H3,(H,67,72)(H,68,92)(H,73,84)(H,74,86)(H,75,88)(H,76,91)(H,77,87)(H,78,90)(H,79,85)(H,80,89)(H4,65,66,69)/t45-,46-,47-,48-,49+,50-,51-,52-,53-/m0/s1
GJKXGJCSJWBJEZ-XRSSZCMZSA-N

Informazioni sul gene

human ... GNRH1(2796) , GNRHR(2798)
mouse ... GNRH1(14714) , GNRHR(14715)
rat ... GNRH1(25194) , GNRHR(81668)

Amino Acid Sequence

pGlu-His-Trp-Ser-Tyr-D-Trp-Leu-Arg-Pro-NHEt

Azioni biochim/fisiol

Long-acting LH-RH agonist.

Pittogrammi

Health hazard
GHS08

Avvertenze

Danger

Indicazioni di pericolo

H360

Consigli di prudenza

P201 - P308 + P313

Classi di pericolo

Repr. 1B

Codice della classe di stoccaggio

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges

Certificati d'analisi (COA)

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S A Colgan et al.
Australian veterinary journal, 97(12), 515-523 (2019-11-21)
A large-scale capture method was developed to enable sterilisation of a macropod population in western Sydney from 2005 to 2018. Until March 2007, free ranging eastern grey kangaroos and red kangaroos were herded into purpose-built 15 m diameter capture yards
Robert M Kirberger et al.
BMC veterinary research, 13(1), 312-312 (2017-11-08)
Cheetahs in captivity have a high prevalence of chronic renal diseases. We ultrasonographically evaluated the renal volumes, a variety of renal dimensions, interarcuate artery resistive indices (RI) as well as aortic diameters and the length of the ventral aspect of the
D Kaya et al.
Reproduction in domestic animals = Zuchthygiene, 52(6), 1104-1112 (2017-10-01)
The goals of this study were as follows: (Experiment 1) to examine the basic capability of canine corpora lutea (CL) to respond to GnRH by assessing expression of gonadotropin-releasing hormone receptor (GnRH-R) in luteal samples collected throughout the luteal lifespan
Wojciech Niżański et al.
Animals : an open access journal from MDPI, 10(12) (2020-12-17)
This article presents B-mode and color Doppler imaging of the prostate and testes in dogs suffering from benign prostate hyperplasia (BPH), and receiving deslorelin acetate (SuprelorinTM) or osaterone acetate (YpozaneTM). The study was planned as a controlled clinical trial, dogs
Marta Cecchetto et al.
Journal of feline medicine and surgery, 19(12), 1224-1230 (2017-02-15)
Objectives The purpose of this study was to assess efficacy of deslorelin, a gonadotropin-releasing hormone (GnRH) agonist marketed in Europe for the control of male dog reproduction, for the postponement of puberty in queens. Methods Nine prepubertal queens aged 3-9
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