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I9529

Sigma-Aldrich

Interleukin-10/Fc Chimera (non-lytic) from mouse

>98% (SDS-PAGE), recombinant, expressed in CHO cells, buffered aqueous solution

Sinonimo/i:

IL-10:Fc (non-lytic)

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About This Item

Numero MDL:
MFCD03457244
Codice UNSPSC:
51111800
NACRES:
NA.32

Origine biologica

mouse

Livello qualitativo

200

Ricombinante

expressed in CHO cells

Saggio

>98% (SDS-PAGE)

Stato

buffered aqueous solution

PM

98 kDa

Confezionamento

pkg of 10 μg

Impurezze

endotoxin, tested

N° accesso UniProt

P18893

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

mouse ... Il10(16153)

Azioni biochim/fisiol

IL-10 (interleukin-10) is an anti-inflammatory cytokine. High levels of IL-10 are present in late syphilis.[1] It is secreted by monocytes and lymphocytes.[2] It suppresses Th1 (T helper) cytokines. IL-10 also controls the differentiation and proliferation of T cells, B cells, natural killer cells, antigen-presenting cells and mast cells.[3]
Possesses the biological function of the IL-10 moiety and a prolonged circulating half-life determined by the Fc domain.

Altre note

Dimeric fusion protein consisting of mouse IL-10 fused to mutant mouse IgG2a Fc.

Stato fisico

Solution in 0.2 μm filtered phosphate buffered saline, pH 7.4.

Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 2

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificati d'analisi (COA)

Lot/Batch Number
SLBC6029V
071K1176

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C Gérard et al.
The Journal of experimental medicine, 177(2), 547-550 (1993-02-01)
Because of its ability to efficiently inhibit in vitro cytokine production by activated macrophages, we hypothesized that interleukin (IL) 10 might be of particular interest in preventing endotoxin-induced toxicity. We therefore examined the effects of IL-10 administration before lipopolysaccharide (LPS)
Maciej Pastuszczak et al.
Human immunology, 76(7), 469-472 (2015-06-24)
Interleukin 10 (IL-10) is a potent anti-inflammatory cytokine. Increased production of IL-10 has been found in late syphilis, presumably creating favorable conditions for bacteria persistence. Single-nucleotide polymorphisms (SNPs) within the promoter of IL-10 gene have been found to influence IL-10
Lucia Elena Alvarado-Arnez et al.
PloS one, 10(9), e0136282-e0136282 (2015-09-05)
Leprosy is a chronic infectious disease that depends on the interplay of several factors. Single nucleotide polymorphisms (SNPs) in host immune related genes have been consistently suggested as participants in susceptibility towards disease. Interleukin-10 (IL-10) is a crucial immunomodulatory cytokine
Manal Mohamed Makhlouf et al.
Laboratory medicine, 45(3), 211-219 (2014-07-23)
Immune thrombocytopenic purpura (ITP) is an acquired autoimmune disorder caused by the production of antiplatelet antibodies. These autoantibodies opsonize platelets for splenic clearance, resulting in low levels of circulating platelets. Interleukin 4 (IL4) and interleukin 10 (IL10) are important immunoregulatory

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