I7659

Monoclonal Anti-Interleukin-1α antibody produced in mouse

clone 3405, purified immunoglobulin, lyophilized powder

• Sinonimo/i: Anti-IL-1α
• Numero MDL: MFCD01632982
• Codice UNSPSC: 51111800
• NACRES: NA.41

Proprietà

• Origine biologica: mouse
• Coniugato: unconjugated
• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: 3405, monoclonal
• Forma fisica: lyophilized powder
• Reattività contro le specie: human
• tecniche: flow cytometry: 25 μg/mL; neutralization: suitable
• Isotipo: IgG1
• N° accesso UniProt: P01583
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... IL1A(3552)

Descrizione

Immunogeno

purified, E. coli-derived recombinant human interleukin-1α.

Azioni biochim/fisiol

Interleukins are proinflammatory cytokines produced on cell injury or trauma. There are two closely related types of interleukins produced by the cell, IL-1α and IL-1β that are produced in response to bacterial infection or LPS. Both IL-1α and IL-1β exert their cellular effects by signaling through IL-1 receptor type 1. The effects of IL-1α are mediated by activation of NF-κB, JNK and MAPK pathways that activated the genes in response to infection and inflammation. Overproduction of IL-1α has been implicated in inflammatory disorders like rheumatoid arthritis and periodontitis.

Stato fisico

Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline with 5% trehalose.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 13 - Non Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)