I3659
Monoclonal Anti-ING1 antibody produced in mouse
~2 mg/mL, clone Cab 3, purified immunoglobulin, buffered aqueous solution
Sinonimo/i:
Anti-Inhibitor of Growth 1, Anti-p33ING1
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About This Item
Numero MDL:
Codice UNSPSC:
12352203
Origine biologica
mouse
Coniugato
unconjugated
Forma dell’anticorpo
purified immunoglobulin
Tipo di anticorpo
primary antibodies
Clone
Cab 3, monoclonal
Stato
buffered aqueous solution
PM
antigen ~33 kDa
Reattività contro le specie
human
Concentrazione
~2 mg/mL
tecniche
immunocytochemistry: suitable
indirect ELISA: suitable
microarray: suitable
western blot: 2-4 μg/mL using K562 total cell extract
Isotipo
IgG1
N° accesso UniProt
Condizioni di spedizione
dry ice
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... ING1(3621)
Descrizione generale
Three alternatively spliced mRNAs of the gene ING1 (inhibitor of growth family member 1), p47ING1a, p33ING1b and p24ING1c, encode for proteins that function as growth inhibitors. The proteins are localized to the nucleus and they have a common C-terminal region. The major isoforms expressed in humans are p47ING1a and p33ING1b. The gene ING1 is mapped to human chromosome 13q34.[1][2]
Immunogeno
recombinant ING1.
Azioni biochim/fisiol
The ING (inhibitor of growth) family of proteins is involved in several cellular processes, such as cell cycle, senescence and apoptosis. They activate acetylation-dependent pathways that in turn, regulate gene expression. The isoform p33ING1b is found to be involved in the regulation of apoptosis. Suppression of p33ING1b expression is found to promote the formation of tumor. On the other hand, increased expression arrests cells at G1 phase of the cell cycle and inhibits the progression of cell cycle. These processes are mediated by interactions with p53 tumor suppressor. Human ING1 proteins are found to be associated with proteins involved in histone acetyltransferase (HAT) activity, such as TRRAP (transformation/transcription domain associated protein), PCAF (P300/CBP-associated factor), CBP (cap binding protein), and p300. The isoform p47ING1a is found to inhibit histone acetylation and bind to histone deacetylase HDAC1 (histone deacetylase 1). The isoform p33ING1b regulates the association between proliferating cell nuclear antigen (PCNA) and p30 that is important for DNA repair and chromatin remodeling.[3][4][5][1]
Stato fisico
Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide.
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Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
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Diego Vieyra et al.
Cancer research, 62(15), 4445-4452 (2002-08-03)
Recently, several novel human ING1 isoforms have been cloned. However,the biochemical functions and the involvement of these proteins in apoptosis remain uncharacterized. We have examined the apoptotic effects and biochemical functions of the two major human ING1 isoforms p47(ING1a) and
D Boland et al.
Hybridoma, 19(2), 161-165 (2000-06-27)
Nine monoclonal antibodies (MAbs) against human and rodent ING1 protein have been generated using an IL6-secreting mouse myeloma line. These antibodies are all effective in recognizing ING1 protein in ELISAs, Western blot assays, and by indirect immunofluorescence. Combining different CAb
M Nagashima et al.
Proceedings of the National Academy of Sciences of the United States of America, 98(17), 9671-9676 (2001-08-02)
The p33ING1 protein is a regulator of cell cycle, senescence, and apoptosis. Three alternatively spliced transcripts of p33ING1 encode p47ING1a, p33ING1b, and p24ING1c. We cloned an additional ING family member, p33ING2/ING1L. Unlike p33ING1b, p33ING2 is induced by the DNA-damaging agents
M Zeremski et al.
Somatic cell and molecular genetics, 23(3), 233-236 (1997-05-01)
A novel gene ING1 was recently cloned and defined as a candidate tumor suppressor gene. Reduced expression and rearrangements of ING1 are found in several tumor cell lines, ING1 overexpression is associated with cell growth arrest and ING1 suppression promotes
Hiromi Kataoka et al.
Cancer research, 63(18), 5785-5792 (2003-10-03)
The ING family of proteins is involved in the regulation of diverse processes ranging from cell cycle and cellular senescence to apoptosis. These effects are most likely through activation of acetylation-dependent pathways that ultimately alter gene expression. Despite reports linking
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