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Merck
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Key Documents

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I0782

Sigma-Aldrich

Imazodan

≥99% (HPLC)

Sinonimo/i:

4,5-Dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone, Cl 914

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About This Item

Formula empirica (notazione di Hill):
C13H12N4O
Numero CAS:
84243-58-3
Peso molecolare:
240.26
Numero MDL:
MFCD00867109
Codice UNSPSC:
41106305
ID PubChem:
24278485

Saggio

≥99% (HPLC)

Colore

yellow, powder

Solubilità

DMSO: 50 mg/mL, clear, yellow

Stringa SMILE

O=C1CCC(=NN1)c2ccc(cc2)-n3ccnc3

InChI

1S/C13H12N4O/c18-13-6-5-12(15-16-13)10-1-3-11(4-2-10)17-8-7-14-9-17/h1-4,7-9H,5-6H2,(H,16,18)
VXMYWVMXSWJFCV-UHFFFAOYSA-N

Informazioni sul gene

human ... PDE3A(5139)
rat ... Pde3a(50678)

Azioni biochim/fisiol

Selective phoshodiesterase III (PDE3) inhibitor.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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T W Gettys et al.
Second messengers and phosphoproteins, 13(1), 37-49 (1990-01-01)
The impact of changes in the activation state of the low Km cAMP phosphodiesterase (PDE) on cAMP output in adipocyte membranes was assessed by measuring the product of cAMP synthesis and degradation in the membrane preparation simultaneously. Crude membranes were
B Zhang et al.
Zhongguo yao li xue bao = Acta pharmacologica Sinica, 14(4), 347-350 (1993-07-01)
Glaucocalyxin A (Gla A) is a new diterpenoid isolated from ethereal extract of the leaves of Rabdosia japonica (Burm f) Hara var glaucocalyx (Maxim) Hara (Labiatae) collected in Northeastern China. When incubated with washed rabbit platelets, Gla A inhibited ADP-
R E Weishaar et al.
European journal of pharmacology, 119(3), 205-215 (1985-12-17)
CI-914 is a novel positive inotropic agent whose cardiotonic activity is not due to inhibition of Na+, K+-ATPase or to stimulation of cardiac beta-receptors. CI-914 also has no direct effect on sarcoplasmic reticulum, mitochondria or adenylate cyclase activity. CI-914 does
C P Nielson et al.
The Journal of allergy and clinical immunology, 86(5), 801-808 (1990-11-01)
Modulation of the human polymorphonuclear leukocyte (PMN) respiratory burst by selective cyclic 3',5' adenosine monophosphate (cAMP) phosphodiesterase (PDE) inhibitors was studied with respect to PDE isozyme characteristics. Zaprinast, an inhibitor of a cyclic guanosine monophosphate (cGMP)-specific PDE (PDE I), at
R E Weishaar et al.
Journal of cyclic nucleotide and protein phosphorylation research, 11(7), 513-527 (1986-01-01)
Two approaches were taken to examine the role which the different forms of phosphodiesterase present in cardiac muscle play in regulating contractility. In an initial study, the effect of selective inhibitors of i) the calmodulin-stimulated phosphodiesterase (M & B 22
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