I0514

Diethyl isocyanomethylphosphonate

>97% (GC)

• Sinonimo/i: Isocyanomethylphosphonic acid diethyl ester
• Formula condensata: CNCH₂P(O)(OC₂H₅)₂
• Numero CAS: 41003-94-5
• Peso molecolare: 177.14
• Beilstein: 4674920
• Numero MDL: MFCD00042951
• Codice UNSPSC: 12352000

Proprietà

• Saggio: >97% (GC)
• Indice di rifrazione: n20/D 1.433 (lit.)
• P. eboll.: 84-87 °C/0.1 mmHg (lit.)
• Densità: 1.105 g/mL at 25 °C (lit.)
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: CCOP(=O)(C[N+]#[C-])OCC
• InChI: 1S/C6H12NO3P/c1-4-9-11(8,6-7-3)10-5-2/h4-6H2,1-2H3; ICURVXBGGDVHDT-UHFFFAOYSA-N

Descrizione

Applicazioni

Reactant for:

• Copper-catalyzed cycloaddition reactions
• Preparation of orally bioavailable diamide prodrugs that lower glucose in diabetic animals through inhibition of fructose-1,6-bisphosphatase
• Synthesis of sterol analogs as antifungal agents against plant pathogens
• Asymmetric synthesis of steroidal 2,5-diketopiperazines prepared via isocyanide chemistry based on stereoselective Ugi four component condensation and subsequent cyclocondensation reactions
• The Passerini reaction

Precursor for synthesis of phosphonic acid analogs of α-amino acids.