H6541
Oncostatin M human
OSM, recombinant, expressed in HEK 293 cells, HumanKine®, suitable for cell culture
Sinonimo/i:
OSM
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About This Item
Prodotti consigliati
Origine biologica
human
Livello qualitativo
Ricombinante
expressed in HEK 293 cells
Saggio
≥95% (SDS-PAGE)
Forma fisica
lyophilized powder
Potenza
≤0.1-1.5 ng/mL EC50
Qualità
endotoxin tested
PM
dimer 30 kDa (glycosylated)
Confezionamento
pkg of 5X10 μg
pkg of 10 μg
tecniche
cell culture | mammalian: suitable
Impurezze
≤1 EU/μg
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
human ... OSM(5008)
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Azioni biochim/fisiol
Oncostatin M (OSM), LIF, G-CSF, IL-6, and CNTF are structurally related members of the same cytokine family sharing similarities in their primary amino acid sequences, predicted secondary structure, and receptor components. OSM is a growth-regulating cytokine, affecting a number of tumor and normal cells. This material was first identified by its ability to inhibit the growth of A375 melanoma cells and other human tumor cells, but not inhibit the growth of normal human fibroblasts. It acts synergistically with TGF β1 to inhibit the proliferation of tumor cells like A375 melanoma cells. It induces an increase in LDL receptor expression and LDL uptake by hepatoma cells. OSM activates synovial fibroblast-like cells to produce urokinase type plasminogen activator. OSM is secreted by macrophages and activated T lymphocytes.
Stato fisico
Lyophilized from a 0.2 μm filtered solution of 1x PBS.
Risultati analitici
The activity was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells (humanerythroleukemic indicator cell line)
Note legali
HumanKine is a registered trademark of Proteintech Group, Inc. and Humanzyme, Inc
Codice della classe di stoccaggio
11 - Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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Huang-Ju Tu et al.
Journal of cellular physiology, 228(5), 983-990 (2012-10-09)
Oncostatin M (OSM) belongs to IL-6 subfamily and is mostly produced by T lymphocytes. High levels of OSM are detected in the pannus of rheumatoid arthritis (RA) patients and it may arouse the inflammation responses in joints and eventually leads
Mong-Lien Wang et al.
Cancer research, 72(22), 6051-6064 (2012-11-10)
Mesenchymal stem cells (MSC) are strongly associated with tumor progression and have been used as novel cell-based agents to deliver anticancer drugs to tumors. However, controversies about the direct involvement of MSCs in tumor progression suggest that MSCs mediate tumor
Sema Becerik et al.
Journal of periodontology, 83(10), 1304-1313 (2012-01-18)
The aim of the present study is to investigate gingival crevicular fluid (GCF) and plasma acute-phase cytokines, interleukin-1β (IL-1β), interleukin-6 (IL-6), interleukin-11 (IL-11), oncostatin M (OSM), and leukemia inhibitory factor (LIF) levels in patients with different periodontal diseases. Eighty individuals
Nikolay Ishkitiev et al.
Journal of endodontics, 38(4), 475-480 (2012-03-15)
We have previously differentiated hepatocyte like cells from deciduous tooth pulp stem and extracted third molar pulp stem cells with a protocol that used fetal bovine serum, but it showed high contaminations of nondifferentiated cells. Both the lower purity of
Thomas Kubin et al.
Cell stem cell, 9(5), 420-432 (2011-11-08)
Cardiomyocyte remodeling, which includes partial dedifferentiation of cardiomyocytes, is a process that occurs during both acute and chronic disease processes. Here, we demonstrate that oncostatin M (OSM) is a major mediator of cardiomyocyte dedifferentiation and remodeling during acute myocardial infarction
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