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GW22849

Sigma-Aldrich

Anti-SLC12A2 (ab2) antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-Solute carrier family 12 member 2

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About This Item

Codice UNSPSC:
12352203

Origine biologica

chicken

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

Reattività contro le specie

human, mouse

Produttore/marchio commerciale

Genway 15-288-22849

tecniche

western blot: suitable

N° accesso NCBI

NP_001037.1

N° accesso UniProt

P55011

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... SLC12A2(6558)

Immunogeno

Immunogen Sequence: GI # 4506975, sequence 114-285
Recombinant solute carrier family 12 (sodium/potassium/chloride transporters), member 2

Applicazioni

Anti-SLC12A2 (ab2) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Azioni biochim/fisiol

The Na-K-Cl cotransporter (NKCC) is a protein that helps in the active transport of sodium, potassium, and chloride into and out of cells. It couples the movement of Na+, K+ and Cl- ions across the plasma membrane of most animal cells and plays a central role in cellular homeostasis and human physiology. The proteins play important roles in Na+ and K+ concentrations in key physiological systems, including cardiac, vascular, renal, nervous and sensory systems. NKCC1 levels and functionality are altered in certain disease states. NKCC1 may play a role in glioma cell migration, the precise mechanism by which ion transporter contributes to Glioblastoma (GB) aggressiveness. Its expression levels are found to be significantly higher in GB and anaplastic astrocytoma tissues than in grade II glioma and normal cortex. It also plays a central role in cellular chloride homeostasis and in epithelial salt transport.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificati d'analisi (COA)

Lot/Batch Number
039K2113
029K2248
019K0497

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Suma Somasekharan et al.
PloS one, 8(12), e82060-e82060 (2013-12-18)
The Na-K-Cl cotransporter (NKCC) couples the movement of Na(+), K(+), and Cl(-) ions across the plasma membrane of most animal cells and thus plays a central role in cellular homeostasis and human physiology. In order to study the structure, function
Suma Somasekharan et al.
The Journal of biological chemistry, 287(21), 17308-17317 (2012-03-23)
The Na-K-Cl cotransporter (NKCC) plays central roles in cellular chloride homeostasis and in epithelial salt transport, but to date little is known about the mechanism by which the transporter moves ions across the membrane. We examined the functional role of
Bo Ding et al.
American journal of physiology. Cell physiology, 306(1), C66-C75 (2013-11-01)
Sodium/potassium/chloride cotransporter (NKCC1) proteins play important roles in Na(+) and K(+) concentrations in key physiological systems, including cardiac, vascular, renal, nervous, and sensory systems. NKCC1 levels and functionality are altered in certain disease states, and tend to decline with age.
Tomas Garzon-Muvdi et al.
PLoS biology, 10(5), e1001320-e1001320 (2012-05-10)
Glioblastoma (GB) is a highly invasive and lethal brain tumor due to its universal recurrence. Although it has been suggested that the electroneutral Na(+)-K(+)-Cl(-) cotransporter 1 (NKCC1) can play a role in glioma cell migration, the precise mechanism by which

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