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GW22766

Sigma-Aldrich

Anti-Fas Antibody

chicken polyclonal

Sinonimo/i:

Anti-CD95

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50 μG
CHF 256.00

CHF 256.00

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50 μG
CHF 256.00

About This Item

Numero MDL:
MFCD00283209
Codice UNSPSC:
12352203
NACRES:
NA.43

CHF 256.00

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Nome del prodotto

Anti-FAS (ab1) antibody produced in chicken, affinity isolated antibody, buffered aqueous solution

Origine biologica

chicken

Livello qualitativo

200

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

Reattività contro le specie

human, mouse, rat

Produttore/marchio commerciale

Genway 15-288-22766

tecniche

western blot: suitable

N° accesso NCBI

NP_000034.1

N° accesso UniProt

P25445

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... FAS(355)

Descrizione generale

The FAS receptor (FasR) is a protein encoded by the TNFRSF6 gene in humans and is mapped to chromosomal band 10q24.1. It is a cell surface antigen expressed on a variety of normal and malignant cells.[1][2]

Immunogeno

Immunogen Sequence: GI # 4507583, sequence 21-165
Recombinant tumor necrosis factor receptor superfamily, member 6 isoform 1

Applicazioni

Anti-FAS (ab1) antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Azioni biochim/fisiol

The FAS receptor (FasR) is associated with programmed cell death (apoptosis). It functions as an apoptosis-signaling cell surface Ag. Mutation of the gene or defective FAS signaling may render the T-cell lymphoblastic lymphomas (T-LBLs) tumor cells resistant to apoptotic cell death.[3]

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

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Certificati d'analisi (COA)

Lot/Batch Number
039K2056
029K1670

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M Villa-Morales et al.
Cell death & disease, 5, e1110-e1110 (2014-03-08)
The acquisition of resistance towards FAS-mediated apoptosis may be required for tumor formation. Tumors from various histological origins exhibit FAS mutations, the most frequent being hematological malignancies. However, data regarding FAS mutations or FAS signaling alterations are still lacking in
I Cascino et al.
Journal of immunology (Baltimore, Md. : 1950), 154(6), 2706-2713 (1995-03-15)
Fas/Apo-1 molecule is an apoptosis-signaling cell surface Ag belonging to the TNFR family. To investigate the possibility that soluble forms of the Fas receptor are expressed in human cells, we analyzed Fas mRNA transcripts obtained from activated peripheral mononuclear cells
P Lichter et al.
Genomics, 14(1), 179-180 (1992-09-01)
The APO-1 (APT) antigen is a cell surface antigen expressed on a variety of normal and malignant cells. Binding of anti-APO-1 antibody to the APO-1 antigen induces programmed cell death (apoptosis). The APO-1 antigen shows homology to the members of
Derek L Clouthier et al.
Journal of immunology (Baltimore, Md. : 1950), 193(10), 5033-5043 (2014-10-05)
The costimulatory TNFR family member GITR can provide important survival signals for CD8 T cells. However, little is known about the regulation of this pathway during a chronic infection. In this study, we show that GITR ligand (GITRL) is maximally
Odilia B J Corneth et al.
Arthritis & rheumatology (Hoboken, N.J.), 66(2), 340-349 (2014-02-08)
Interleukin-17A (IL-17A) signals through the IL-17 receptor (IL-17R) A/C heterodimer. IL-17RA serves as a common receptor subunit for several IL-17 cytokine family members. Lack of IL-17RA signaling may therefore have additional effects beyond those of lack of IL-17A alone. The

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