GW22683

Anti-ENO1 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• Codice UNSPSC: 12352203
• NACRES: NA.41

Proprietà

• Origine biologica: chicken
• Livello qualitativo: 200
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: buffered aqueous solution
• Reattività contro le specie: human, mouse, rat
• Produttore/marchio commerciale: Genway 15-288-22683
• tecniche: western blot: suitable
• N° accesso NCBI: NP_001419.1
• N° accesso UniProt: P06733
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... ENO1(2023)

Descrizione

Descrizione generale

Enolase 1 (ENO1 or ENOα) is a type of enolase enzyme, which in mammals, has three different isoforms namely, α-, β- and γ-enolase. It is an essential cytoplasmic glycolytic enzyme, and has a molecular weight of 48kDa. An alternatively spliced form resides in the nucleus, which has a molecular weight of 37kDa.[1]

Immunogeno

Immunogen Sequence: GI # 4503571, sequence 161-320

Recombinant enolase 1

Applicazioni

Anti-ENO1 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Azioni biochim/fisiol

Enolase 1(α-enolase) is a homodimer composed of 2 α subunits. ENO1 is involved in tumor progression and prognosis of human glioma. Overexpression of ENO1 is associated with progression of glioma while its knockdown leads to suppressed cell growth, migration and invasion progression by inactivating the PI3K/Akt pathway in glioma cells.[1] The lower expression of ENO1 decreases the response to hypoxia and enhances the sensitivity of the cells to radiation therapy. It may act as a drug target for the treatment of breast cancer.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)