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Documenti fondamentali

GW21321

Sigma-Aldrich

Anti-RGS16 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-RGSR, Anti-Regulator of G-protein signaling 16

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

chicken

Livello qualitativo

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Stato

buffered aqueous solution

Reattività contro le specie

human, mouse, rat

Produttore/marchio commerciale

Genway 15-288-21321

tecniche

western blot: suitable

N° accesso NCBI

N° accesso UniProt

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... RGS16(6004)

Immunogeno

Immunogen Sequence: GI # 4506513, sequence 130-202
Recombinant regulator of G-protein signalling 16

Applicazioni

Anti-RGS16 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Azioni biochim/fisiol

Regulator of G-protein signaling 16 is a protein encoded by the RGS16 gene in humans and is mapped to chromosome 1q25-1q31. It is found to be expressed in 17 human gastrointestinal cancer cell lines. RGS16 expression is higher in colorectal cancer (CRC) tissue when compared to normal tissue. It can act as a predictive marker for patient prognosis of CRC. Loss of RGS16 in some breast tumors enhances PI3K signaling elicited by growth factors and thereby promotes proliferation and TKI evasion downstream of HER activation.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)


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B E Snow et al.
Gene, 206(2), 247-253 (1998-04-04)
Regulators of G-protein signaling (RGS) constitute a family of GTPase-activating proteins with varying tissue-specific expression patterns and G-protein alpha subunit specificities. Here, we describe the molecular cloning of the human RGS-r/RGS16 cDNA, encoding a predicted polypeptide of 23kDa that shows
Norikatsu Miyoshi et al.
Annals of surgical oncology, 16(12), 3507-3514 (2009-09-18)
The RGS family, comprising 22 homologues of proteins, plays a role in cellular proliferation, differentiation, membrane trafficking, and embryonic development through the involvement of the mitogen-activated protein kinase signaling pathway. In order to demonstrate the importance of RGS16 expression for
Genqing Liang et al.
The Journal of biological chemistry, 284(32), 21719-21727 (2009-06-11)
Aberrant activity of the phosphatidylinositol 3-kinase (PI3K) pathway supports growth of many tumors including those of breast, lung, and prostate. Resistance of breast cancer cells to targeted chemotherapies including tyrosine kinase inhibitors (TKI) has been linked to persistent PI3K activity

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