GW21046

Anti-CCR2 antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

• Sinonimo/i: Anti-Chemokine (C-C motif) receptor 2 isoform A, Anti-MCP-1 receptor
• Numero MDL: MFCD01864606
• Codice UNSPSC: 12352203

Proprietà

• Origine biologica: chicken
• Coniugato: unconjugated
• Forma dell’anticorpo: affinity isolated antibody
• Tipo di anticorpo: primary antibodies
• Clone: polyclonal
• Stato: buffered aqueous solution
• Reattività contro le specie: human
• Produttore/marchio commerciale: Genway 15-288-21046
• tecniche: western blot: suitable
• N° accesso NCBI: NP_000638.1
• N° accesso UniProt: O95950
• Condizioni di spedizione: wet ice
• Temperatura di conservazione: −20°C
• Informazioni sul gene: human ... CCR2(1231)

Descrizione

Descrizione generale

CCR2 (chemokine (C-C motif) receptor 2) belongs to the chemokine receptor family, which are small (8-10kDa) G-protein coupled receptors (GPCR). This family is subdivided into four families called CC, CXC, CX3C and XC. CCR2 belongs to the CC family, and has its ligand-binding domain in its exoplasmic N-terminal. Its C-terminal is involved in intracellular signaling. It is constitutively expressed by monocytes, and is found on T-cells, naïve B-cells, NK (natural killer) cells, dendritic cells and basophils.

Immunogeno

Immunogen Sequence: GI # 4502633, sequence 1-45

Recombinant chemokine (C-C motif) receptor 2 isoform A

Applicazioni

Anti-CCR2 antibody produced in chicken is suitable for western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.
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Azioni biochim/fisiol

C-C chemokine receptor type 2 (CCR2) is an important chemokine for monocyte aggregation and transendothelial monocyte migration. CCR2 plays an important role in extravasation and transmigration of monocytes under inflammatory conditions. It is involved in the growth and invasion of prostate cancer (PCa). CCR2 expression is very important for CCL2-induced proliferation and invasion of PC-3M cells. CCR2 can also act as a promising molecular target for prevention of PCa growth and metastasis.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 12 - Non Combustible Liquids
• Classe di pericolosità dell'acqua (WGK): WGK 1
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)