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GW21035

Sigma-Aldrich

Anti-MIP-1β antibody produced in chicken

affinity isolated antibody, buffered aqueous solution

Sinonimo/i:

Anti-Chemokine C-C motif ligand 4 isoform 1, Anti-Macrophage inflammatory protein 1β, Anti-SCYA4, Anti-Small inducible cytokine A4

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About This Item

Codice UNSPSC:
12352203
NACRES:
NA.41

Origine biologica

chicken

Livello qualitativo

200

Coniugato

unconjugated

Forma dell’anticorpo

affinity isolated antibody

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

buffered aqueous solution

Reattività contro le specie

human

Produttore/marchio commerciale

Genway 15-288-21035

tecniche

indirect ELISA: suitable
western blot: suitable

N° accesso NCBI

NP_002975.1

N° accesso UniProt

P13236

Condizioni di spedizione

wet ice

Temperatura di conservazione

−20°C

modifica post-traduzionali bersaglio

unmodified

Informazioni sul gene

human ... CCL4(6351)

Descrizione generale

MIP-1β (macrophage inflammatory protein 1β) is a member of the CC chemokine (cysteine-cysteine) family, and is produced by monocytes and macrophages. This protein exists as a homodimer. It acts as a ligand to the GPCR (G-protein coupled receptor) called CCR5 (CC chemokine receptor 5).

Immunogeno

Immunogen Sequence: GI # 4506845, sequence 27-92
Recombinant chemokine C-C motif ligand 4 isoform 1

Applicazioni

Anti-MIP-1β antibody produced in chicken is suitable for indirect ELISA and western blotting analysis at a dilution of 1:500, for tissue or cell staining at a dilution of 1:200.

Azioni biochim/fisiol

Chemokine (C-C motif) ligand 4 (CCL4) is a principal regulator of macrophage migration and signals through CCR5. CCR5 is linked to several protein kinases including the src kinase Lyn, PI3K, focal adhesion related kinase Pyk2 and members of the MAPK family that help in regulating macrophage chemotaxis. CCL4 is released at the site of inflammation in sarcoidosis.

Stato fisico

Solution in phosphate buffered saline containing 0.02% sodium azide.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

10 - Combustible liquids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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A Barczyk et al.
International journal of immunopathology and pharmacology, 27(2), 185-193 (2014-07-10)
Sarcoidosis is a granulomatous disease with an increased accumulation of T cells in lungs as a result of on-site proliferation and chemotaxis induced by chemokines. It has already been demonstrated that CCL3-5 levels were increased in BAL fluid of sarcoidosis
Melissa A McCornack et al.
The Journal of biological chemistry, 278(3), 1946-1956 (2002-11-02)
Chemokines comprise a family of proteins that function in the immune response to recruit leukocytes to sites of infection. This recruitment is believed to be carried out by the establishment of a chemokine gradient by the binding of chemokines to
Isaac G Sakala et al.
Infection and immunity, 81(6), 1974-1983 (2013-03-20)
Tuberculosis remains one of the top three leading causes of morbidity and mortality worldwide, complicated by the emergence of drug-resistant Mycobacterium tuberculosis strains and high rates of HIV coinfection. It is important to develop new antimycobacterial drugs and immunomodulatory therapeutics
Li Zhang et al.
Proceedings of the National Academy of Sciences of the United States of America, 103(38), 13985-13990 (2006-09-12)
Chemokines (chemotactic cytokines) comprise a large family of proteins that recruit and activate leukocytes, giving chemokines a major role in both immune response and inflammation-related diseases. The poxvirus-encoded viral CC chemokine inhibitor (vCCI) binds to many CC chemokines with high
Ricky Cheung et al.
Journal of leukocyte biology, 86(4), 833-845 (2009-07-22)
MIP-1beta/CCL4 is a principal regulator of macrophage migration and signals through CCR5. Several protein kinases are linked to CCR5 in macrophages including the src kinase Lyn, PI3K, focal adhesion related kinase Pyk2, and members of the MAPK family, but whether

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