F9397

Flutamide

Non-steroidal anti-androgen drug

• Sinonimo/i: 2-Methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide
• Formula empirica (notazione di Hill): C₁₁H₁₁F₃N₂O₃
• Numero CAS: 13311-84-7
• Peso molecolare: 276.21
• NACRES: NA.77
• PubChem Substance ID: 24278446
• UNSPSC Code: 51111800
• EC Number: 236-341-9
• MDL number: MFCD00072009

Proprietà

• Nome del prodotto: Flutamide,
• Quality Segment: 100
• originator: Schering Plough
• SMILES string: CC(C)C(=O)Nc1ccc(c(c1)C(F)(F)F)[N+]([O-])=O
• InChI: 1S/C11H11F3N2O3/c1-6(2)10(17)15-7-3-4-9(16(18)19)8(5-7)11(12,13)14/h3-6H,1-2H3,(H,15,17)
• InChI key: MKXKFYHWDHIYRV-UHFFFAOYSA-N
• Gene Information: human ... AR(367) ; mouse ... Ar(11835) ; rat ... Ar(24208)

Descrizione

Application

Flutamide has been used to effect of testosterone on Glial cell-derived neurotrophic factor (Gdnf) mRNA production in vitro. It has also been used to study the effects of flutamide on anogenital distance and nipple retention.

Biochem/physiol Actions

Flutamide is a non-steroidal anti-androgen drug. It consists of a nitroaromatic structure. Flutamide is a potent competitor of testosterone and dihydrotestosterone receptors. It is a potent hepatotoxin.

Features and Benefits

This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• pictograms: GHS08,GHS07,GHS09
• signalword: Warning
• hcodes: H302,H351,H361,H373,H411
• pcodes: P202 - P260 - P264 - P273 - P301 + P312 - P308 + P313
• Hazard Classifications: Acute Tox. 4 Oral - Aquatic Chronic 2 - Carc. 2 - Repr. 2 - STOT RE 2
• target_organs: Liver
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type P3 (EN 143) respirator cartridges