F7301
Fibroblast Growth Factor-18 human
>95% (SDS-PAGE and HPLC), recombinant, expressed in E. coli, lyophilized powder
Sinonimo/i:
FGF-18
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Cambia visualizzazione
| Taglio della confezione | SKU | Disponibilità | Prezzo |
|---|---|---|---|
| 25 μg | Per conoscere la disponibilità, visualizza il carrello | CHF 608.00 |
Informazioni su questo articolo
CHF 608.00
Per conoscere la disponibilità, visualizza il carrello
Servizio Tecnico
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Permettici di aiutartibiological source
human
Quality Level
recombinant
expressed in E. coli
assay
>95% (SDS-PAGE and HPLC)
form
lyophilized powder
potency
≤0.5 ng/mL
mol wt
predicted mol wt 21.2 kDa
packaging
pkg of 25 μg
storage condition
avoid repeated freeze/thaw cycles
impurities
endotoxin, tested
1 of 1
Questo articolo | |||
|---|---|---|---|
| assay >95% (SDS-PAGE and HPLC) | assay ≥97% (SDS-PAGE) | assay ≥97% (SDS-PAGE) | assay >97% (SDS-PAGE) |
| recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli | recombinant expressed in E. coli |
| biological source human | biological source human | biological source human | biological source human |
| Quality Level 200 | Quality Level 200 | Quality Level 200 | Quality Level 100 |
| form lyophilized powder | form lyophilized powder | form lyophilized powder | form lyophilized powder |
| packaging pkg of 25 μg | packaging pkg of 25 μg | packaging pkg of 4X25 μg, pkg of 25 μg | packaging pkg of 25 μg |
General description
FGF18 (fibroblast growth factor 18) is a member of the FGF family, and is a part of the FGF8 subfamily, which also includes FGF8 and FGF17. It is a paracrine-acting protein, and does not undergo alternative splicing. It is produced as a precursor of 207 amino acids, from which the signal peptide of 27 hydrophobic amino acids is cleaved of.[1] This gene is localized to human chromosome 5q35.1, which produces a protein of 21.2kDa.[2]
Biochem/physiol Actions
FGF-18 is a heparin binding growth factor, which stimulates the proliferation and activation of cells that express the FGF receptors.
FGF18 (fibroblast growth factor 18) functions in both developing and adult organisms, and plays a predominant role in skeletal development. It is a putative early marker for prostate and ovarian cancer, and has potential as a target in the same.[1] It mediates gene profiling, and has anticatabolic effects mediated through Timp1 (tissue inhibitor of metalloproteinases). Thus, it has confers protection on adult articular cartilage.[3] In mice embryos, inactivation of this gene results in death due to aberrations in alveologenesis and skeleton development.[2]
Stimulates the proliferation and activation of cells that express the FGF receptors.
Physical form
Lyophilized from a 0.2 μm filtered solution in 10 mM Tris, pH 8.0 + 20mM NaCl.
Analysis Note
The biological activity is determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF receptors.
signalword
Warning
hcodes
Hazard Classifications
Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
target_organs
Respiratory system
Classe di stoccaggio
11 - Combustible Solids
wgk
WGK 2
flash_point_f
Not applicable
flash_point_c
Not applicable
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The crystal structure of fibroblast growth factor 18 (FGF18).
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Articoli
Fibroblast growth factors in cell culture and various growth factors for your research
Contenuto correlato
Instructions
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| F7301-25UG | 04061833619469 |
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