F2145

Monoclonal Anti-Factor V antibody produced in mouse

clone HV-1, purified immunoglobulin, buffered aqueous solution

• Numero MDL: MFCD00164642
• Codice UNSPSC: 12352203
• NACRES: NA.43

Proprietà

• Forma dell’anticorpo: purified immunoglobulin
• Tipo di anticorpo: primary antibodies
• Clone: HV-1, monoclonal
• Stato: buffered aqueous solution
• Reattività contro le specie: human
• tecniche: ELISA: suitable; dot blot: suitable; neutralization: suitable
• Isotipo: IgG1
• Condizioni di spedizione: dry ice
• Temperatura di conservazione: −20°C
• modifica post-traduzionali bersaglio: unmodified
• Informazioni sul gene: human ... F5(2153)

Descrizione

Descrizione generale

Monoclonal Anti-Factor V (mouse IgG1 isotype) is derived from the HV-1 hybridoma, produced by the fusion of mouse myeloma Sp2/0-Ag14 cells and splenocytes from BALB/c mouse immunized with Factor V, purified from human plasma. Blood coagulation factor V, also known as, proaccelerin or labile factor. The activated factor V (factor Va) is a calcium dependent heterodimer composed of heavy chain (~105 kDa) and light chain (~73 kDa).

Specificità

The antibody inhibits the activity of Factor V as measured by the prothrombin time (PT) assay.

Immunogeno

Factor V from pooled normal human plasma

Applicazioni

Monoclonal Anti-Factor V antibody produced in mouse has been used in dot blot and enzyme linked immunosorbent assay (ELISA).

Azioni biochim/fisiol

Blood coagulation factor V is an essential component of the prothrombinase complex that catalyzes the rapid conversion of prothrombin to thrombin and is involved in intrinsic and extrinsic coagulation pathways. About 20% of blood factor V is contained within platelets. Factor V circulates in the plasma as a single chain glycoprotein with little or no intrinsic procoagulant activity. It is activated through limited proteolysis by thrombin, factor Xa, or the factor V activator from Russell′s viper venom (RW-V). Activated protein C (APC) with its cofactor protein S, inactivates factors Va and VIIIa to provide a major natural anticoagulant system. APC resistance known as factor V Leiden (FV Leiden) is a common hereditary thrombophilia Factor V mutation, caused by arginine substitution into glutamine at position 506 (R506Q).

Stato fisico

Solution in 0.01 M phosphate buffered saline, pH 7.4, containing 15 mM sodium azide as a preservative.

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

Informazioni sulla sicurezza

• Codice della classe di stoccaggio: 10 - Combustible liquids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable