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E7781

Erastin

Name: Erastin
Brand: SIGMA

≥98% (HPLC), powder, ferroptosis inducer

Sinonimo/i:

2-[1-[4-[2-(4-chlorophenoxy)acetyl]-1-piperazinyl]ethyl]-3-(2-ethoxyphenyl)-4(3H)-Quinazolinone

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Informazioni su questo articolo

Formula empirica (notazione di Hill):

C₃₀H₃₁ClN₄O₄

Numero CAS:

571203-78-6

Peso molecolare:

547.04

UNSPSC Code:

12352200

PubChem Substance ID:

329799073

NACRES:

NA.77

MDL number:

MFCD09837984

Assay:

≥98% (HPLC)

Form:

powder

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Proprietà

Nome del prodotto

Erastin, ≥98% (HPLC)

Quality Segment

100

assay

≥98% (HPLC)

form

powder

color

white to beige

solubility

DMSO: 5 mg/mL, clear (warmed)

storage temp.

−20°C

SMILES string

CCOc1ccccc1N2C(=O)c3ccccc3N=C2C(C)N4CCN(CC4)C(=O)COc5ccc(Cl)cc5

InChI

1S/C30H31ClN4O4/c1-3-38-27-11-7-6-10-26(27)35-29(32-25-9-5-4-8-24(25)30(35)37)21(2)33-16-18-34(19-17-33)28(36)20-39-23-14-12-22(31)13-15-23/h4-15,21H,3,16-20H2,1-2H3

InChI key

BKQFRNYHFIQEKN-UHFFFAOYSA-N

Gene Information

human ... hRas(3265)
mouse ... hRas(15461)
rat ... hRas(293621)

Descrizione

General description

Erastin is a cell-permeable piperazinyl-quinazolinone. It interacts with antiporter system Xc^-.

Application

Erastin has been used:

as a positive control for inducing ferroptosis in hepatic stellate cell (HSC)
to induce ferroptosis and in transferrin internalization assay of human fibrosarcoma HT1080 cells
to induce ferroptosis of muscle-derived cell lines

Biochem/physiol Actions

Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS (i.e. HRAS, KRAS). Erastin produces ferroptosis, a non-apoptotic tumor cell death, by altering mitochondrial voltage-dependent anion channel (VDAC) gating allowing cations to enter mitochondria and leading to release of oxidative species causing oxidative cell death.

Erastin is an antitumor agent selective for tumor cells bearing oncogenic RAS.

Features and Benefits

This compound is a featured product for Apoptosis research. Click here to discover more featured Apoptosis products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

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Questo articolo	SML2231	SML0607	G0544
Sigma-Aldrich E7781 Erastin	Sigma-Aldrich SML2231 Erasin	Sigma-Aldrich SML0607 Ceranib-2	Sigma-Aldrich G0544 GR 103691
description ≥98% (HPLC)	description ≥98% (HPLC)	description ≥98% (HPLC)	description ≥98% (HPLC), solid
assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)	assay ≥98% (HPLC)
form powder	form powder	form powder	form solid
Quality Level 100	Quality Level -	Quality Level 100	Quality Level 100
storage temp. −20°C	storage temp. 2-8°C	storage temp. −20°C	storage temp. 2-8°C
solubility DMSO: 5 mg/mL, clear (warmed)	solubility DMSO: 2 mg/mL, clear	solubility DMSO: 20 mg/mL, clear	solubility DMSO: soluble >5 mg/mL at 60 °C
color white to beige	color white to beige	color white to beige	color white

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Classe di stoccaggio

11 - Combustible Solids

wgk

WGK 3

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number

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