E7138

Ethosuximide

T-type calcium channel antagonist

• Sinonimo/i: 2-Ethyl-2-methylsuccinimide
• Formula empirica (notazione di Hill): C₇H₁₁NO₂
• Numero CAS: 77-67-8
• Peso molecolare: 141.17
• NACRES: NA.77
• PubChem Substance ID: 24278423
• UNSPSC Code: 12352111
• EC Number: 201-048-7
• MDL number: MFCD00072123

Proprietà

• Nome del prodotto: Ethosuximide,
• Quality Segment: 100
• solubility: ethanol: 100 mg/mL
• SMILES string: O=C1NC(CC1(C)CC)=O
• InChI: 1S/C7H11NO2/c1-3-7(2)4-5(9)8-6(7)10/h3-4H2,1-2H3,(H,8,9,10)
• InChI key: HAPOVYFOVVWLRS-UHFFFAOYSA-N
• Gene Information: human ... CACNA1G(8913), CACNA1H(8912), CACNA1I(8911)

Descrizione

Application

Ethosuximide has been used:

• to confirm its effect on spike wave discharges (SWD) in rats
• to examine its effects on spontaneous locomotion and anxiety-related thigmotaxis behaviours in zebrafish larvae of wild type
• as a model drug for the treatment of epilepsy in vivo(4)

Biochem/physiol Actions

Ethosuximide is an anticonvulsant drug and an antagonist for T-type calcium channel. It is known to prevent spike wave discharges, characterized in absence seizures.

Features and Benefits

This compound is featured on the Calcium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• pictograms: GHS07
• signalword: Warning
• hcodes: H302
• pcodes: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Gloves