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Merck
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Documenti fondamentali

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E6264

Sigma-Aldrich

[D-Pen2,5, p-Cl-Phe4]-Enkephalin

≥97% (HPLC)

Sinonimo/i:

[pCl-Phe4]-DPDPE

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About This Item

Formula empirica (notazione di Hill):
C30H38ClN5O7S2
Numero CAS:
122507-47-5
Peso molecolare:
680.24
Numero MDL:
MFCD00080350
Codice UNSPSC:
12352200

Saggio

≥97% (HPLC)

Composizione

Peptide content, ~70%

Temperatura di conservazione

−20°C

Stringa SMILE

CC1(C)SSC(C)(C)[C@@H](NC(=O)[C@@H](N)Cc2ccc(O)cc2)C(=O)NCC(=O)N[C@@H](Cc3ccc(Cl)cc3)C(=O)N[C@H]1C(O)=O

Informazioni sul gene

human ... OPRD1(4985)
mouse ... OPRD1(18386)
rat ... OPRD1(24613)

Amino Acid Sequence

Tyr-D-Pen-Gly-p-Chloro-Phe-D-Pen [Disulfide Bridge: 2-5]

Azioni biochim/fisiol

Selective agonist at the δ opioid receptor.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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E V Varga et al.
Molecular pharmacology, 50(6), 1619-1624 (1996-12-01)
In the present study, we replaced the third extracellular loop of the human delta-opioid receptor with that of the human mu-opioid receptor. A modified polymerase chain reaction overlap extension method was used to achieve the exact splicing in the chimera
F Niroomand et al.
Naunyn-Schmiedeberg's archives of pharmacology, 354(5), 643-649 (1996-11-01)
Although both opioid receptors and endogenous opioids are abundant in cardiac tissues, the signal transduction pathways of opioids in cardiac sarcolemmal membranes have yet to be identified. In highly purified canine cardiac sarcolemmal membranes, binding of the opioid receptor antagonist
R J Knapp et al.
European journal of pharmacology, 291(2), 129-134 (1995-10-15)
2-methyl-4a alpha-(3-hydroxyphenyl)-1,2,3,4,4a,5,12,12a alpha-octahydro-quinolino[2,3,30g]isoquinoline (TAN-67) is a nonpeptidic delta-opioid receptor agonist. This report describes its receptor binding affinity and agonist potency at human and mouse delta and mu-opioid receptors. The binding affinities of TAN-67 and the cyclic enkephalin analog, (D-Pen2, 4'-Cl-Phe4
Michael J McCarthy et al.
Psychopharmacology, 213(4), 735-744 (2010-10-14)
The synthesis and release of met-enkephalin and β-endorphin, endogenous ligands for δ-opioid peptide receptors (DOPrs), are altered following nicotine administration and may play a role in nicotine addiction. To investigate the consequences of altered opioidergic activity on DOPr expression, coupling
D C Brown et al.
American journal of veterinary research, 62(4), 496-499 (2001-05-01)
To measure oxytocin concentrations in blood and CSF following central administration of opioid agonists in dogs. 5 male dogs. In a crossover design, CSF and blood were collected immediately before and 15 and 30 minutes after cisternal administration of D-Ala2
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