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D8428

Sigma-Aldrich

Decorin from bovine articular cartilage

salt-free, lyophilized powder

Sinonimo/i:

Decorin protein

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About This Item

Numero MDL:
MFCD00283027
Codice UNSPSC:
12352202
NACRES:
NA.75

Origine biologica

bovine articular cartilage

Livello qualitativo

200

Forma fisica

salt-free, lyophilized powder

PM

~100 kDa

Confezionamento

glass bottle of 0.5 mg

tecniche

cell culture | mammalian: suitable

Solubilità

PBS: ≥2.00 mg/mL, clear, colorless to yellow

N° accesso UniProt

P21793

Temperatura di conservazione

−20°C

Informazioni sul gene

cow ... DCN(280760)

Categorie correlate

Descrizione generale

Decoran is a small proteoglycan composed of a chondroitin/dermatan sulfate glycosaminoglycans attached to a 40 kDa core protein. It is found primarily in the extracellular matrix of articular cartilage. Decorin interacts with collagen types I and II via its core protein wherein it delays fibrillogenesis. Decorin also interacts with fibronectin, thrombospondin and TGF-β isoforms, and the EGF-receptor.
Decorin from bovine articular cartilage is a proteoglycan that belongs to the small leucine-rich repeat proteoglycans and proteins (SLRPs) family. Decorin is present in almost all tissues. It has a protein core composed of leucine-rich repeats (LRRs), flanked by two cysteine-rich regions.

Applicazioni

Decorin from bovine articular cartilage has been used in solid phase binding assay (ELISA), binding assays, binding inhibition assay, parasite binding assays, scaffold fabrication, quartz crystal microbalance assay, inhibition of CSA (chondroitin sulphate A) binding assay and glycans and glycan biotinylation.

Azioni biochim/fisiol

Decorin plays an important role in guiding the proper assembly of collagen during fibrillogenesis. Deficiency in decorin results in altered tissue structure and function. It controls growth factors like EGF and TGF-β. Decorin blocks aggregation of fibrils into fibers and fibrillogenesis in cell-free constructs of polymerized type I collagen.

Altre note

Decorin is an approx. 100 kDa proteoglycan consisting of a 40 kDa core protein and one chondroitin or dermatan sulfate glycosaminoglycan chain. From 0.2 μm filtered solution prior to lyophilization.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Seda Duran G Ler et al.
Indian journal of ophthalmology, 69(2), 369-373 (2021-01-20)
The aims of this study were to evaluate the effects of decorin (DCN) in rat oxygen-induced retinopathy (OIR) model and to compare the results with those of bevacizumab. Twenty-eight newborn Sprague-Dawley rats were randomly divided into four groups. Group I
Full-length recombinant Plasmodium falciparum VAR2CSA binds specifically to CSPG and induces potent parasite adhesion-blocking antibodies.
Khunrae P, et al.
Journal of Molecular Biology, 397(3), 826-834 (2010)
Effects of decorin proteoglycan on fibrillogenesis, ultrastructure, and mechanics of type I collagen gels.
Reese S P, et al.
Matrix Biology, 32(7-8), 414-423 (2013)
Structural and functional insight into how the Plasmodium falciparum VAR2CSA protein mediates binding to chondroitin sulfate A in placental malaria.
Clausen T M, et al.
The Journal of Biological Chemistry, 287(28), 23332-23345 (2012)
Several domains from VAR2CSA can induce Plasmodium falciparum adhesion-blocking antibodies.
Salanti A, et al.
Malaria Journal, 9(1), 11-11 (2010)
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