D6152

Domoic acid

≥90% (HPLC)

• Formula empirica (notazione di Hill): C₁₅H₂₁NO₆
• Numero CAS: 14277-97-5
• Peso molecolare: 311.33
• Beilstein: 46376
• Numero MDL: MFCD06795841
• Codice UNSPSC: 12352202
• ID PubChem: 24894006
• NACRES: NA.77

Proprietà

• Saggio: ≥90% (HPLC)
• Forma fisica: powder
• Temperatura di conservazione: −20°C
• Stringa SMILE: OC([C@H](C)/C=C/C=C([C@@H]1[C@H](CC(O)=O)[C@@H](C(O)=O)NC1)/C)=O
• InChI: 1S/C15H21NO6/c1-8(4-3-5-9(2)14(19)20)11-7-16-13(15(21)22)10(11)6-12(17)18/h3-5,9-11,13,16H,6-7H2,1-2H3,(H,17,18)(H,19,20)(H,21,22)/b5-3+,8-4-/t9-,10+,11-,13+/m1/s1; VZFRNCSOCOPNDB-AOKDLOFSSA-N
• Informazioni sul gene: human ... GRIK1(2897)

Descrizione

Descrizione generale

Domoic acid, a heterocyclic amino acid neurotoxin is synthesized by various marine algaes. It possess some structural similarity to kainic acid.

Applicazioni

Domoic acid has been used:

• as an excitatory neurotoxin to determine brain transcriptional response
• to study its cytotoxic, genotoxic and immunotoxic effects on the marine mussel M. edulis
• to study its neurobehavioral effects on mouse fetuses

Azioni biochim/fisiol

Domoic acid is a potent agonist at receptors for excitatory amino acids glutamate and kainate. It has highest affinity for AMPA/kainate receptor of any kainate agonist. It can causes excessive excitation of neurons leading to depletion of energy stores.

Domoic acid serves as an antihelminthic. It is capable of binding and stimulating the kainic acid glutamate receptor in the central nervous system.

Potent glutamate receptor and kainate receptor agonist.

Caratteristiche e vantaggi

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.

This compound is featured on the Glutamate Receptors (Ion Channel Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Danger
• Indicazioni di pericolo: H302,H370
• Consigli di prudenza: P260 - P264 - P270 - P301 + P312 - P308 + P311 - P405
• Classi di pericolo: Acute Tox. 4 Oral - STOT SE 1
• Organi bersaglio: Central nervous system
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Dispositivi di protezione individuale: dust mask type N95 (US), Eyeshields, Gloves