Passa al contenuto
Merck
Tutte le immagini(2)

Documenti fondamentali

Visualizza tutta la documentazione

D4434

Sigma-Aldrich

Dichloromethylenediphosphonic acid disodium salt

Sinonimo/i:

Cl2MDP, Clodronate disodium, Clodronic acid disodium salt, DMDP

Autenticatiper visualizzare i prezzi riservati alla tua organizzazione & contrattuali
Tutte le immagini(2)

About This Item

Formula condensata:
CH2O6Cl2Na2P2
Numero CAS:
22560-50-5
Peso molecolare:
288.86
Numero CE:
245-078-9
Numero MDL:
MFCD01632786
Codice UNSPSC:
12352106
ID PubChem:
24278371
NACRES:
NA.77

Stato

powder

Livello qualitativo

300

Solubilità

water: 49.00-51.00 mg/mL, clear, colorless

Temperatura di conservazione

room temp

Stringa SMILE

[Na+].[Na+].OP([O-])(=O)C(Cl)(Cl)P(O)([O-])=O

InChI

1S/CH4Cl2O6P2.2Na/c2-1(3,10(4,5)6)11(7,8)9;;/h(H2,4,5,6)(H2,7,8,9);;/q;2*+1/p-2
HJKBJIYDJLVSAO-UHFFFAOYSA-L

Informazioni sul gene

rat ... Man2a1(25478) , Si(497756)

Azioni biochim/fisiol

Analog of pyrophosphate ion that inhibits the osteoclastic activity leading to bone resorption and osteoporosis. The compound is used in cancer research, especially in skeletal metastases and breast carcinoma. When entrapped in liposomes, it is used for macrophage-selective depletion (macrophage "suicide" technique), especially in spleen and liver. Found also to inhibit collagenase and matrix metalloproteinase1.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Scegli una delle versioni più recenti:

Certificati d'analisi (COA)

Lot/Batch Number
0000369112
0000315047
0000369112
0000315047
0000232917

Non trovi la versione di tuo interesse?

Se hai bisogno di una versione specifica, puoi cercare il certificato tramite il numero di lotto.

Cerca un COA

Possiedi già questo prodotto?

I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.

Visita l’Archivio dei documenti

I clienti hanno visto anche

Slide 1 of 4

1 of 4

Liposome Kit: Lipid mixtures for the preparation of liposomes lyophilized powder

Sigma-Aldrich

L4395

Liposome Kit: Lipid mixtures for the preparation of liposomes

N-Methyl-D-aspartic acid ≥98% (TLC), solid

Sigma-Aldrich

M3262

N-Methyl-D-aspartic acid

Dimetil solfossido puriss. p.a., ACS reagent, ≥99.9% (GC)

Sigma-Aldrich

41640

Dimetil solfossido

L-α-fosfatidilcolina egg yolk, Type XVI-E, ≥99% (TLC), lyophilized powder

Sigma-Aldrich

P3556

L-α-fosfatidilcolina

Valérie Lebrun et al.
Clinical science (London, England : 1979), 125(11), 501-511 (2013-06-14)
Alcohol consumption is a major cause of liver disease. It also associates with increased cardiovascular risk and Type 2 diabetes. ALD (alcoholic liver disease) and NAFLD (non-alcoholic fatty liver disease) share pathological features, pathogenic mechanisms and pattern of disease progression.
N Van Rooijen
Journal of immunological methods, 124(1), 1-6 (1989-11-13)
Macrophages form an important cell population involved in numerous immunological processes. Techniques which eliminate these cells, in order to permit 'in vivo' studies of their function are generally imperfect and for that reason we have developed a method using the
Michiko Itoh et al.
PloS one, 8(12), e82163-e82163 (2013-12-19)
Although macrophages are thought to be crucial for the pathogenesis of chronic inflammatory diseases, how they are involved in disease progression from simple steatosis to non-alcoholic steatohepatitis (NASH) is poorly understood. Here we report the unique histological structure termed "hepatic
O Teronen et al.
Calcified tissue international, 61(1), 59-61 (1997-07-01)
Interstitial collagenase present in human jaw cyst extract and purified human fibroblast-type collagenase (MMP-1) were both efficiently inhibited in vitro by clodronate, an osteoactive, antiresorptive bisphosphonate. The IC50 of clodronate to inhibit MMP-1 is 150 microM. These findings suggest an
Maren Richter et al.
Brain pathology (Zurich, Switzerland), 30(3), 589-602 (2019-11-27)
During Alzheimer's disease (AD) progression, microglial cells play complex roles and have potentially detrimental as well as beneficial effects. The use of appropriate model systems is essential for characterizing and understanding the roles of microglia in AD pathology. Here, we
Visualizza tutti i documenti correlati

Il team dei nostri ricercatori vanta grande esperienza in tutte le aree della ricerca quali Life Science, scienza dei materiali, sintesi chimica, cromatografia, discipline analitiche, ecc..

Contatta l'Assistenza Tecnica.