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D103

Sigma-Aldrich

(±)-2,3-Dichloro-α-methylbenzylamine hydrochloride

solid

Sinonimo/i:

DCMB, LY-78335

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About This Item

Formula empirica (notazione di Hill):
C8H9Cl2N · HCl
Numero CAS:
39226-94-3
Peso molecolare:
226.53
Numero MDL:
MFCD00055225
Codice UNSPSC:
12352202
ID PubChem:
24278157

Stato

solid

Colore

white

Solubilità

H2O: soluble (Solutions may be stored for 1-2 days at 4 °C.)
ethanol: soluble (Solutions may be stored for 1-2 days at 4 °C.)

Stringa SMILE

Cl[H].CC(N)c1cccc(Cl)c1Cl

Informazioni sul gene

human ... PNMT(5409)

Azioni biochim/fisiol

PNMT inhibitor.

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

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Certificati d'analisi (COA)

Lot/Batch Number

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Y Goshima et al.
The Journal of pharmacology and experimental therapeutics, 235(1), 248-253 (1985-10-01)
High-K+ (30 mM)-evoked release of endogenous epinephrine in hypothalamic slices from three rats in the presence of tetrodotoxin, 3 X 10(-7) M, was measured by high-performance liquid chromatography with an electrochemical detector. Spontaneous and evoked release of epinephrine was markedly
H Ueda et al.
The Journal of pharmacology and experimental therapeutics, 232(2), 507-512 (1985-02-01)
Using high-performance liquid chromatography with electro-chemical detector, we measured field impulse (5 or 2 Hz)- and high K+ (20 mM)-evoked release of endogenous norepinephrine from rat hypothalamic slices. Release by impulses at 5 Hz was tetrodotoxin-sensitive and both types of
Lowering of epinephrine concentration in rat brain by 2,3-dichloro-alpha-methyl-benzylamine, an inhibitor of norepinephrine N-methyltransferase.
R W Fuller et al.
Biochemical pharmacology, 26(21), 2087-2090 (1977-11-01)
I N Mefford et al.
Alcoholism, clinical and experimental research, 14(1), 53-57 (1990-02-01)
The probable involvement of brain epinephrine in the expression of the acute sedative and intoxicating effects of ethanol and pentobarbital is demonstrated. Two selective inhibitors of phenylethanolamine N-methyltransferase (PNMT), LY134046 and LY78335, proved to be potent and long-lasting antagonists of
Properties of 8,9-dichloro-2,3,4,5-tetrahydro-1H-2-benzazepine, an inhibitor of norepinephrine N-methyltransferase.
R W Fuller et al.
Biochemical pharmacology, 30(11), 1345-1352 (1981-06-01)
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