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C9301

Sigma-Aldrich

Chicken Collagen Type II

from chicken sternal cartilage, powder, suitable for cell culture

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About This Item

Numero CAS:
9007-34-5
Numero CE:
232-697-4
Numero MDL:
MFCD00130825
Codice UNSPSC:
12352202
NACRES:
NA.75

product name

Collagen from chicken sternal cartilage, Type II (Miller), powder, BioReagent, suitable for cell culture

Origine biologica

chicken (Sternal cartilage)

Livello qualitativo

300

Tipo

Type II (Miller)

Nome Commerciale

BioReagent

Forma fisica

powder

Confezionamento

glass bottle of 100 mg
poly bottle of 25 mg
glass bottle of 5 mg

Concentrazione

60-80% (biuret)

tecniche

cell culture | mammalian: suitable

Copertura della superficie

6‑10 μg/cm2

Solubilità

acetic acid: 0.5-2.0 mg/mL (Dissolve for several hours at 2-8 °C, occasionally swirling.)

N° accesso UniProt

P02460

Specificità del legame

Peptide Source: Fibrinogen

Condizioni di spedizione

wet ice

Temperatura di conservazione

2-8°C

Informazioni sul gene

chicken ... COL2A1(395069)

Categorie correlate

Descrizione generale

Collagen is made of three polypeptide chains. Type 2 collagen is ubiquitously present in the hyaline cartilage. It is a homotrimer made of three α1 chains. Type 2 collagen is also predominant in nucleus pulposus of the vertebral disc and vitreous body of the eye. The proteoglycan obtained from the chicken sternal cartilage is similar to type nine collagen structure.
Collagen is classified into a number of structurally and genetically distinct types. We use the nomenclature proposed by Bornstein and Traub. Do not confuse Sigma type designations with recognized collagen classification types.

Applicazioni

Collagen from chicken sternal cartilage has been used:
  • in enzyme–linked immunosorbent assay (ELISA).
  • chondrocyte-mediated tissue production in vitro.
  • induction, treatment and assessment of collagenα induced arthritis (CIA).
  • cell proliferation assay.
  • as a coating for cell culture surfaces.

Azioni biochim/fisiol

Collagen breaks down metabolically in the body to release N-telopeptide, which is the N-terminus of collagen. There is also C-telopeptide, which is presumably the C-terminus. N-telopeptide is released in urine, and its detection in diagnostic tests is used to screen for osteoporosis.

Caratteristiche e vantaggi

This collagen has been tested in culture with mammalian cells to verify it is low in endotoxin content.

Altre note

Major component of articular cartilage.

Nota sulla preparazione

Prepared by a modification of the method of Trentham, D.E., et al.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Derivation of Chondrogenic Cells from Human Embryonic Stem Cells for Cartilage Tissue Engineering
Toh W S
Methods in Molecular Biology (2014)
Blockade of the interleukin?7 receptor inhibits collagen?induced arthritis and is associated with reduction of T cell activity and proinflammatory mediators.
Hartgring S A, et al.
Arthritis and Rheumatism, 62(9), 2716-2725 (2010)
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