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Documenti

C8088

Sigma-Aldrich

Cantharidic acid

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About This Item

Formula empirica (notazione di Hill):
C10H14O5
Numero CAS:
28874-45-5
Peso molecolare:
214.22
Numero MDL:
MFCD00047137
Codice UNSPSC:
12352200
ID PubChem:
24278339

Saggio

≥98% (TLC)

Forma fisica

solid

Solubilità

DMSO: soluble
ethanol: soluble

Stringa SMILE

OC(=O)[C@@H]1[C@H]2CC[C@H](O2)[C@@H]1C(O)=O

InChI

1S/C8H10O5/c9-7(10)5-3-1-2-4(13-3)6(5)8(11)12/h3-6H,1-2H2,(H,9,10)(H,11,12)/t3-,4+,5-,6+
GXEKYRXVRROBEV-FBXFSONDSA-N

Azioni biochim/fisiol

Useful for inhibiting PP1 and PP2A during purification of phosphorylated proteins, IC50 = 53 nM.

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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Y M Li et al.
Proceedings of the National Academy of Sciences of the United States of America, 89(24), 11867-11870 (1992-12-15)
The toxic effects of cantharidin from blister beetles and its analogs, including the herbicide endothall, are attributable to their high affinity and specificity for a cantharidin-binding protein (CBP). An ammonium sulfate precipitate of mouse liver cytosol was purified by five
Y M Li et al.
Biochemical pharmacology, 46(8), 1435-1443 (1993-10-19)
The target site for cantharidin (CA) and its analogues was isolated recently from mouse liver and identified as protein phosphatase (PP2A) in the heterodimeric form known as PP2A2. The most toxic CA analogue, endothall thioanhydride (ETA) (mouse i.p. LD50 0.3
Koyuki Kondo et al.
PloS one, 10(12), e0144803-e0144803 (2015-12-23)
Upon desiccation, some tardigrades enter an ametabolic dehydrated state called anhydrobiosis and can survive a desiccated environment in this state. For successful transition to anhydrobiosis, some anhydrobiotic tardigrades require pre-incubation under high humidity conditions, a process called preconditioning, prior to
Masanori Ikeda et al.
Scientific reports, 7(1), 8794-8794 (2017-08-20)
For faithful chromosome segregation, the formation of stable kinetochore-microtubule attachment and its monitoring by the spindle assembly checkpoint (SAC) are coordinately regulated by mechanisms that are currently ill-defined. Here, we show that polo-like kinase 1 (Plk1), which is instrumental in
Hanne B Moeller et al.
Journal of cell science, 127(Pt 14), 3174-3183 (2014-05-31)
The post-translational modifications (PTMs) phosphorylation and ubiquitylation regulate plasma membrane protein function. Here, we examine the interplay between phosphorylation and ubiquitylation of the membrane protein aquaporin-2 (AQP2) and demonstrate that phosphorylation can override the previously suggested dominant endocytic signal of

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