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C7934

Sigma-Aldrich

2-Chloro-N6-cyclopentyl-1-deazaadenosine

Sinonimo/i:

DCCA

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About This Item

Formula empirica (notazione di Hill):
C16H21ClN4O4
Numero CAS:
113646-62-1
Peso molecolare:
368.82
Numero MDL:
MFCD00055218
Codice UNSPSC:
12352204
ID PubChem:
329775156

Stringa SMILE

OCC1OC(C(O)C1O)n2cnc3c(NC4CCCC4)cc(Cl)nc23

InChI

1S/C16H21ClN4O4/c17-11-5-9(19-8-3-1-2-4-8)12-15(20-11)21(7-18-12)16-14(24)13(23)10(6-22)25-16/h5,7-8,10,13-14,16,22-24H,1-4,6H2,(H,19,20)
ZQSTWOIIMKNFPE-UHFFFAOYSA-N

Azioni biochim/fisiol

A selective A1 adenosine receptor agonist

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Gloves, type N95 (US)

Certificati d'analisi (COA)

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Bin Yu et al.
BMC genomics, 19(1), 478-478 (2018-06-20)
Apoptosis is associated with some human diseases, including cancer, autoimmune disease, neurodegenerative disease and ischemic damage, etc. Apoptosis proteins subcellular localization information is very important for understanding the mechanism of programmed cell death and the development of drugs. Therefore, the
Nam D Nguyen et al.
PLoS computational biology, 16(4), e1007677-e1007677 (2020-04-03)
The molecular mechanisms and functions in complex biological systems currently remain elusive. Recent high-throughput techniques, such as next-generation sequencing, have generated a wide variety of multiomics datasets that enable the identification of biological functions and mechanisms via multiple facets. However
C Cano et al.
The Journal of pharmacology and experimental therapeutics, 261(2), 660-668 (1992-05-01)
The subtype of adenosine receptor linked to cardiac prostacyclin (PGI2) synthesis, measured as immunoreactive 6-keto-PGF1 alpha, was investigated in the rabbit heart perfused with Krebs' buffer at 20 ml/min. Adenosine (6.4-50 nmol) decreased 6-keto-PGF1 alpha synthesis, coronary perfusion pressure (PP)
E A van Schaick et al.
Naunyn-Schmiedeberg's archives of pharmacology, 356(6), 827-837 (1998-02-07)
In this study we investigated the relationship between the pharmacokinetics and the cardiovascular and electroencephalogram (EEG) effects of three adenosine agonists with differing lipophilicity. Conscious normotensive rats received either 600 microg/kg N6-(p-sulphophenyl) adenosine (SPA), 200 microg/kg N6-cyclopentyladenosine (CPA) or 600
Eduardo Pérez-Valera et al.
Scientific reports, 9(1), 6760-6760 (2019-05-03)
Bacterial genes responsible for resistance to antibiotic agents (ARG) are spread from livestock to soil through application of manure, threatening environmental and human health. We investigated the mechanisms of ARG dissemination and persistence to disentangle i) the influence of nutrients
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