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C7870

Sigma-Aldrich

Chalcone 4 hydrate

≥98% (HPLC)

Sinonimo/i:

(E)-1-(4-Chlorophenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one hydrate

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About This Item

Formula empirica (notazione di Hill):
C16H13ClO3 · xH2O
Numero CAS:
1202866-96-3
Peso molecolare:
288.73 (anhydrous basis)
Numero MDL:
MFCD12912407
Codice UNSPSC:
51111800
ID PubChem:
329775154
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

solid

Condizioni di stoccaggio

protect from light

Colore

yellow

Solubilità

DMSO: >20 mg/mL

Temperatura di conservazione

−20°C

Stringa SMILE

O.COc1cc(ccc1O)\C=C\C(=O)c2ccc(Cl)cc2

InChI

1S/C16H13ClO3.H2O/c1-20-16-10-11(3-9-15(16)19)2-8-14(18)12-4-6-13(17)7-5-12;/h2-10,19H,1H3;1H2/b8-2+;
PXVQKTVKTBMRIW-VOKCZWNHSA-N

Azioni biochim/fisiol

Chalcone 4 is a potent, selective inhibitor of the chemokine CXCL12 via direct binding. It is also a small molecule anti-ligand (or neutraligand) of CXCR4 and CXCR7. The chemokine CXCL12 (stromal cell-derived factor-1) and its receptors play pivotal roles in inflammatory responses, normal vascular and neuronal development, as well as in infectious diseases and cancer. Chalcone 4 binds to and activates the chemokine receptors CXCR4 and CXCR7 and stimulates a rapid receptor-mediated intracellular calcium mobilization and signaling through a Pertussis toxin sensitive Gi protein. Chalcone 4 potently and selectively inhibits CXCL12 binding to CXCR4 and CXCR7, and consequent CXCL12-evoked calcium cellular responses. Chalcone 4 binds to the chemokine CXCL12, but not to its receptors.

Caratteristiche e vantaggi

This compound is featured on the Chemokine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Pittogrammi

Environment
GHS09

Avvertenze

Warning

Indicazioni di pericolo

H410

Consigli di prudenza

P273 - P501

Classi di pericolo

Aquatic Acute 1 - Aquatic Chronic 1

Codice della classe di stoccaggio

13 - Non Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

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