C7861

Citalopram hydrobromide

≥98% (HPLC), powder, serotonin uptake inhibitor

• Sinonimo/i: 1-[3-(Dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofurancarbonitrile hydrobromide
• Formula empirica (notazione di Hill): C₂₀H₂₁FN₂O · HBr
• Numero CAS: 59729-32-7
• Peso molecolare: 405.30
• Numero CE: 261-890-6
• Numero MDL: MFCD02101306
• Codice UNSPSC: 12352200
• ID PubChem: 24278335
• NACRES: NA.77

Proprietà

• Nome del prodotto: Citalopram hydrobromide, ≥98% (HPLC)
• Saggio: ≥98% (HPLC)
• Stato: powder
• Solubilità: chloroform: soluble; methanol: soluble
• Ideatore: Forest Labs
• Temperatura di conservazione: 2-8°C
• Stringa SMILE: Br[H].CN(C)CCCC1(OCc2cc(ccc12)C#N)c3ccc(F)cc3
• InChI: 1S/C20H21FN2O.BrH/c1-23(2)11-3-10-20(17-5-7-18(21)8-6-17)19-9-4-15(13-22)12-16(19)14-24-20;/h4-9,12H,3,10-11,14H2,1-2H3;1H; WIHMBLDNRMIGDW-UHFFFAOYSA-N
• Informazioni sul gene: human ... HTR1A(3350) , HTR1B(3351) , HTR1D(3352) , HTR1E(3354) , HTR1F(3355) , HTR2A(3356) , HTR2B(3357) , HTR2C(3358) , HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242) , HTR4(3360) , HTR5A(3361) , HTR5B(645694) , HTR6(3362) , HTR7(3363) , SLC6A4(6532)

Descrizione

Descrizione generale

Citalopram is a bicyclic phthalene derivative.[1] It initiates serotonergic activity, which produces antidepressant action. Citalopram hydrobromide reverses memory impairment.[2] It is used to treat obsessive compulsive disorder,[1] panic disorder, sociophobia and premenstrual dysphoric disorder.[3]

Applicazioni

Citalopram hydrobromide has been used:

• to examine its effects on sirt mRNA and mammalian sirtuins (SIRT) expression in mice[4]
• to monitor body temperature and antidepressant-like behavioral responses in the forced swim test for rats[5][6]
• for 5-hydroxytryptamine (5-HT) competition uptake assays[7]

Azioni biochim/fisiol

Potent and selective serotonin uptake inhibitor (K_i = 5.4 nM); antidepressant

Caratteristiche e vantaggi

This compound was developed by Forest Labs. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS08,GHS07
• Avvertenze: Warning
• Indicazioni di pericolo: H302,H336,H361d,H412
• Consigli di prudenza: P202 - P261 - P264 - P273 - P301 + P312 - P308 + P313
• Classi di pericolo: Acute Tox. 4 Oral - Aquatic Chronic 3 - Repr. 2 - STOT SE 3
• Organi bersaglio: Central nervous system
• Codice della classe di stoccaggio: 11 - Combustible Solids
• Classe di pericolosità dell'acqua (WGK): WGK 2
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Gloves, type N95 (US)