C7555
Concanavalin A from Canavalia ensiformis (Jack bean)
agarose conjugate, Type VI, saline suspension
Sinonimo/i:
ConA
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About This Item
Codice UNSPSC:
12161501
NACRES:
NA.32
Prodotti consigliati
Origine biologica
Canavalia ensiformis
Coniugato
agarose conjugate
Tipo
Type VI
Forma fisica
saline suspension
Grado di funzionalizzazione
15-30 mg concanavalin A protein per mL
Matrice
cross-linked 4% beaded agarose
Attivazione matrice
cyanogen bromide
Gruppi immobilizzati alla matrice
amino
Braccio spaziatore
1 atom
Temperatura di conservazione
2-8°C
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Descrizione generale
Concanavalin A (Con A), isolated from Jack beans (Canavalia ensiformis), is a mannose or glucose specific-binding lectin. The lectin is a tetramer and each subunit possesses a saccharide-binding site. Con A can be isolated by affinity chromatography with dextrans.
Applicazioni
Concanavalin A (Con A) has been used for enzyme immobilization.
Used for the purification of glycoproteins containing mannose
Azioni biochim/fisiol
Concanavalin A (Con A) is a T cell mitogen that can activate the lymphocytes.
Con A can induce tumor cell death through autophagy.
Con A can induce tumor cell death through autophagy.
Con A is not blood group specific but has an affinity for terminal α-D-mannosyl and α-D-glucosyl residues. Ca2+ and Mn2+ ions are required for activity. Con A dissociates into dimers at pH 5.6 or below. Between pH 5.8 and pH 7.0, Con A exists as a tetramer; above pH 7.0 higher aggregates are formed. Con A exhibits mitogenic activity which is dependent on its degree of aggregation. Succinylation results in an active dimeric form which remains a dimer above pH 5.6.
Stato fisico
Suspension in 1.0 M NaCl + 0.1 M potassium phosphate, pH 6.0, with 1 mM CaCl2, 1 mM MgCl2 and 1 mM MnCl2 containing preservative
Risultati analitici
Where reported, agglutination activity is expressed in μg/ml and is determined from serial dilutions in phosphate buffered saline, pH 6.8, containing Ca2+ and Mn2+ of a 1 mg per mL solution. This activity is the lowest concentration to agglutinate a 2% suspension of human erythrocytes after 1 hr incubation at 25 °C.
Avvertenze
Danger
Indicazioni di pericolo
Consigli di prudenza
Classi di pericolo
Resp. Sens. 1 - Skin Sens. 1
Codice della classe di stoccaggio
12 - Non Combustible Liquids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Certificati d'analisi (COA)
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