C6617

CBIQ

≥98% (HPLC), solid

• Sinonimo/i: 4-Chlorobenzo[f]isoquinoline
• Formula empirica (notazione di Hill): C₁₃H₈NCl
• Numero CAS: 32081-28-0
• Peso molecolare: 213.66
• Numero MDL: MFCD02179769
• Codice UNSPSC: 12352200
• ID PubChem: 24724450
• NACRES: NA.77

Proprietà

• Livello qualitativo: 100
• Saggio: ≥98% (HPLC)
• Stato: solid
• Colore: off-white
• Solubilità: DMSO: 15 mg/mL
• Stringa SMILE: Clc1nccc2c1ccc3ccccc23
• InChI: 1S/C13H8ClN/c14-13-12-6-5-9-3-1-2-4-10(9)11(12)7-8-15-13/h1-8H; SHQLTRRYZVBEMR-UHFFFAOYSA-N

Descrizione

Azioni biochim/fisiol

CBIQ is a cystic fibrosis transmembrane conductance regulator (CFTR) activator; intermediate-conductance calcium-sensitive K⁺ channel (KCNN4) activator.

CBIQ is an activator of the cystic fibrosis transmembrane conductance regulator (CFTR) and the intermediate-conductance calcium-sensitive K+ channel (KCNN4). CBIQ is a novel tool for a new ion channel; first activator of ΔF508 CFTR, the mutant form of CFTR chloride channel present in 75% of cystic fibrosis patients. Other benzoquinolines act at the normal CFTR but not at ΔF508 CFTR. CBIQ also activates KCNN4, which hyperpolarizes airway epithelial cells to promote anion flux, a further benefit in cystic fibrosis.

Caratteristiche e vantaggi

This compound is featured on the Chloride Channels and Potassium Channels pages of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Pittogrammi: GHS06,GHS05
• Avvertenze: Danger
• Indicazioni di pericolo: H301,H315,H318,H335
• Consigli di prudenza: P280 - P301 + P310 + P330 - P302 + P352 - P305 + P351 + P338 + P310
• Classi di pericolo: Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• Organi bersaglio: Respiratory system
• Codice della classe di stoccaggio: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• Classe di pericolosità dell'acqua (WGK): WGK 3
• Punto d’infiammabilità (°F): Not applicable
• Punto d’infiammabilità (°C): Not applicable
• Dispositivi di protezione individuale: Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges