C6019 is supplied in powder form. It is soluble in Chloroform at 50.0 - 52.0 mg/ml. But the information on the absorption molecular coefficient of clotrimazole is currently unavailable. However, I conducted an extensive literature search and found some relevant information. Clotrimazole showed absorption maxima (λ max) at 263 nm, and linearity was obtained by concentration versus absorbance for clotrimazole with a correlation coefficient of r = 0.999.
C6019
Clotrimazole
98.5-100.5% (dry basis), powder, Ca²⁺-activated K⁺ channels inhibitor
Sinonimo/i:
1-(o-Chloro-α,α-diphenylbenzyl)imidazole, 1-(o-Chlorotrityl)imidazole, 1-[(2-Chlorophenyl)diphenylmethyl]-1H-imidazole
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Cambia visualizzazione
| A voi/SKU | Disponibilità | Prezzo |
|---|---|---|
5 g | Per conoscere la disponibilità, visualizza il carrello | CHF 148.00 |
25 g | Per conoscere la disponibilità, visualizza il carrello | CHF 347.00 |
100 g | Per conoscere la disponibilità, visualizza il carrello | CHF 838.00 |
Informazioni su questo articolo
Formula empirica (notazione di Hill):
C22H17ClN2
Numero CAS:
Peso molecolare:
344.84
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352200
EC Number:
245-764-8
MDL number:
Form:
powder
Servizio Tecnico
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Permettici di aiutartiNome del prodotto
Clotrimazole,
form
powder
Quality Segment
antibiotic activity spectrum
fungi
mode of action
cell membrane | interferes, protein synthesis | interferes
originator
Schering Plough
SMILES string
Clc1ccccc1C(c2ccccc2)(c3ccccc3)n4ccnc4
InChI
1S/C22H17ClN2/c23-21-14-8-7-13-20(21)22(25-16-15-24-17-25,18-9-3-1-4-10-18)19-11-5-2-6-12-19/h1-17H
InChI key
VNFPBHJOKIVQEB-UHFFFAOYSA-N
Gene Information
human ... ABCB1(5243), CYP17A1(1586), CYP3A4(1576)
mouse ... Abcb1a(18671), Abcb1b(18669)
General description
Chemical structure: imidazole
Application
Clotrimazole has been used:
- to study the upregulation of the gene ERG11 that codes for an azole target enzyme lanosterol demethylase, in Candida species, upon treatment with azole antibiotics
- to study the development of resistance in Candida species isolated from patients undergoing prolonged antifungal treatment
- to induce stress granules via mitochondrial stress
- for the inhibition of in vitro formation of high density sickle cells induced by treatment with 1-chloro-2,4-dinitrobenzene (CDNB)
- to inhibit cytochrome P450 enzyme in cell cultures
Biochem/physiol Actions
Clotrimazole is a specific inhibitor of Ca2+-activated K+ channels. It is an antifungal azole. Clotrimazole is a derivative of imidazole and has similar antimicrobial action and activity to ketoconazole. It inhibits cytochrome P450-dependent 14α-demethylase, which is critical to ergosterol biosynthesis. The accumulated 14α-methylated sterols change the membrane structure of sensitive fungi, altering cell membrane permeability.
Features and Benefits
This compound is featured on the Potassium Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
This compound was developed by Schering Plough. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.
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Questo articolo | |||
|---|---|---|---|
| description - | description Pharmaceutical Secondary Standard; Certified Reference Material | description European Pharmacopoeia (EP) Reference Standard | description British Pharmacopoeia (BP) Reference Standard |
| form powder | form - | form - | form solid |
| Quality Level 200 | Quality Level 300 | Quality Level - | Quality Level - |
| originator Schering Plough | originator - | originator - | originator - |
| mode of action cell membrane | interferes, protein synthesis | interferes | mode of action - | mode of action - | mode of action - |
| antibiotic activity spectrum fungi | antibiotic activity spectrum - | antibiotic activity spectrum - | antibiotic activity spectrum - |
| Gene Information human ... ABCB1(5243), CYP17A1(1586), CYP3A4(1576) | Gene Information - | Gene Information - | Gene Information - |
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signalword
Warning
hcodes
Hazard Classifications
Acute Tox. 4 Oral - Aquatic Acute 1 - Aquatic Chronic 1 - Eye Irrit. 2 - Skin Irrit. 2
Classe di stoccaggio
11 - Combustible Solids
wgk
WGK 3
ppe
dust mask type N95 (US), Eyeshields, Gloves
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Please provide the absorption molecular coefficient of clotrimazole and the solvent used to quantify my clotrimazole solutions.
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