C5736
Monoclonal Anti-μ-Calpain (Calpain I, subunit p80) antibody produced in mouse
clone 15C10, purified immunoglobulin, buffered aqueous glycerol solution
Sinonimo/i:
Anti-CANP, Anti-CANP1, Anti-CANPL1, Anti-SPG76, Anti-muCANP, Anti-muCL
Autenticati per visualizzare i prezzi organizzativi e contrattuali.
Informazioni su questo articolo
Conjugate:
unconjugated
Clone:
15C10, monoclonal
Application:
ELISA (i), IP, WB CL
Citations:
10
biological source
mouse
Quality Level
conjugate
unconjugated
antibody form
purified immunoglobulin
antibody product type
primary antibodies
clone
15C10, monoclonal
form
buffered aqueous glycerol solution
species reactivity
bovine, mouse, rat, human
technique(s)
immunoprecipitation (IP): 2-5 μL (native and denaturing conditions), indirect ELISA: suitable, western blot (chemiluminescent): 1:1,000
isotype
IgG1
UniProt accession no.
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... CAPN1(823), CAPNS1(826)
mouse ... Capn1(12333), Capns1(12336)
rat ... Capn1(29153), Capns1(29156)
General description
Calpain-1 (CAPN1), an intracellular, calcium-dependent cysteine protease, has four domains, such as, the N-terminal anchor helix region, the CysPc protease domain, the C2 domain-like domain and the penta-EF-hand domain (PEF). CAPN1 codes for μ-calpain protein. CAPN1 gene is abundantly expressed in the central nervous system (CNS). This gene is located on human chromosome 11q13.1.
Immunogen
purified human μ-calpain from placenta (calpain-I, protein kinase-C activating factor, E.C. 3.4.22.17).
Application
Biochem/physiol Actions
Calpain-1 (CAPN1) plays a key role in microtubular regulation, cerebellar development, synaptic plasticity, synaptic restructuring, axon maturation and maintenance. CAPN1 activation is essential to provide a neuro-protective role in central nervous system (CNS). Mutations on CAPN1 gene results in spastic paraplegia 76 (SPG7), a complicated form of hereditary spastic paraplegia (HSP).
Specifically recognizes the 80 kDa subunit of μ-calpain as well as two smaller proteins that are presumed to be degradation products.
Physical form
Solution in 20 mM sodium phosphate, 150 mM sodium chloride, 50% glycerol, pH 7.5, and 3 mM sodium azide.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Still not finding the right product?
Provate il nostro Motore di ricerca dei prodotti per restringere le opzioni.
Classe di stoccaggio
10 - Combustible liquids
wgk
WGK 1
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
Eyeshields, Gloves, multi-purpose combination respirator cartridge (US)
Scegli una delle versioni più recenti:
Possiedi già questo prodotto?
I documenti relativi ai prodotti acquistati recentemente sono disponibili nell’Archivio dei documenti.
Contenuto correlato
Instructions
Fang Peng et al.
Orphanet journal of rare diseases, 14(1), 83-83 (2019-04-27)
Hereditary spastic paraplegias (HSP) are of great clinical and genetic heterogeneity. According to the clinical features, HSP can be divided into pure or complicated subtypes which combined with other neurological symptoms including cerebellar ataxia. Up to date, 78 loci or
Aakash Shetty et al.
European journal of medical genetics, 62(12), 103605-103605 (2018-12-21)
To characterize the phenotype of CAPN1 (SPG76) mutations in patients diagnosed with hereditary spastic paraplegia (HSP). The CAPN1 gene, located on chromosome 11q13.1, is a protein-coding gene involved in neuronal plasticity, migration, microtubular regulation and cerebellar development. Several families with
Bruno A Cisterna et al.
Biochimica et biophysica acta, 1862(11), 2168-2176 (2016-09-01)
Denervated fast skeletal muscles undergo atrophy, which is associated with an increase in sarcolemma permeability and protein imbalance. However, the mechanisms responsible for these alterations remain largely unknown. Recently, a close association between de novo expression of hemichannels formed by
Numero articolo commerciale globale
| SKU | GTIN |
|---|---|
| C5736-100UG | 04061837896712 |