C5612
Anti-CD30 Ligand antibody produced in goat
affinity isolated antibody, lyophilized powder
Sinonimo/i:
Anti-CD30L
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About This Item
Numero MDL:
Codice UNSPSC:
12352203
Origine biologica
goat
Coniugato
unconjugated
Forma dell’anticorpo
affinity isolated antibody
Tipo di anticorpo
primary antibodies
Clone
polyclonal
Forma fisica
lyophilized powder
Reattività contro le specie
mouse
tecniche
indirect ELISA: 0.5-1.0 μg/mL
western blot: 0.1-0.2 μg/mL
N° accesso UniProt
Temperatura di conservazione
−20°C
Informazioni sul gene
mouse ... Tnfsf8(21949)
Descrizione generale
CD30 Ligand (CD30L) is a type II membrane glycoprotein of the tumor necrosis factor (TNF) superfamily. It is expressed on the cell surface of activated T cells, B cells, and monocytes. CD30L is also present in other cells, including mature dendritic cells, macrophages and mast cells. CD30L is also reffered to as Tnfsf8 (Tumor necrosis factor ligand superfamily member 8).
Immunogeno
purified recombinant mouse CD30 ligand (amino acids 68-239) extracellular domain, expressed in NSO cells.
Applicazioni
Anti-CD30 antibody produced in goat is suitable for indirect ELISA at a concentration of 0.5-1.0μg/mL and western blotting at a concentration of 0.1-0.2μg/mL.
Azioni biochim/fisiol
CD30L (CD30 ligand) along with CD30 is involved in activation and proliferation of T and B cells. They are also involved in the regulation of initial artherosclerosis development. CD30L/CD30 is crucial for maintenance and activation of IL (Interleukin)-17A-producing γδ T cells. CD30L/CD30 causes down-regulation of IL-2, resulting in Th17 differentiation of CD4+ T cells. CD30L helps in memory phenotype CD4+ T cells-mediated protection against infection with Listeria monocytogenes. CD30L/CD30 signaling is critical for Th1 response against Mycobacterium bovis bacillus Calmette-Guérin (BCG) infection. They are also linked to allergic rhinitis pathogenesis in mice. CD30L/CD30 signaling is involved in pathogenesis of inflammatory bowel diseases.
Stato fisico
Lyophilized from a 0.2 μm filtered solution in phosphate buffered saline.
Esclusione di responsabilità
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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Codice della classe di stoccaggio
13 - Non Combustible Solids
Classe di pericolosità dell'acqua (WGK)
WGK 3
Punto d’infiammabilità (°F)
Not applicable
Punto d’infiammabilità (°C)
Not applicable
Dispositivi di protezione individuale
Eyeshields, Gloves, type N95 (US)
Certificati d'analisi (COA)
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X Sun et al.
Mucosal immunology, 6(6), 1191-1201 (2013-04-04)
CD30 ligand (CD30L, CD153), a member of the tumor necrosis factor (TNF) superfamily, and its receptor CD30 are important for differentiation and activation of CD4(+) T helper type 17 (Th17) cells. In this report, we demonstrate that the interleukin 17A
H J Gruss et al.
The American journal of pathology, 149(2), 469-481 (1996-08-01)
The CD30 ligand (CD30L) is a type II transmembrane glycoprotein of the tumor necrosis factor ligand superfamily. Recent cloning of CD30L has enabled studies to explore its function and tissue distribution. For instance, recombinant CD30L has been shown to co-stimulate
Amanda C Foks et al.
Arteriosclerosis, thrombosis, and vascular biology, 32(12), 2862-2868 (2012-10-23)
Costimulatory molecules tightly control immune responses by providing positive signals that promote T-cell activation or by transducing inhibitory signals that limit T-cell responses. CD30 and CD30L are members of the tumor necrosis factor receptor superfamily and are involved in the
Xun Sun et al.
Gastroenterology, 134(2), 447-458 (2008-02-05)
A CD30-ligand (CD30L) is a 40-kilodalton, type II membrane-associated glycoprotein belonging to the tumor necrosis factor family. Serum levels of soluble CD30 increased in inflammatory bowel diseases (IBD), suggesting that CD30L/CD30 signaling is involved in the pathogenesis of IBD. In
Kenji Umeda et al.
Microbiology and immunology, 55(9), 645-656 (2011-06-28)
CD30 ligand (CD30L, CD153) is a type II membrane-associated glycoprotein belonging to the tumor necrosis factor family. It is shown here that CD30L knock out (KO) mice are highly susceptible to primary infection with Listeria monocytogenes as assessed by the
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