C5238

Chlorotoxin from Leiurus quinquestriatus (north Africa)

recombinant, expressed in E. coli, ≥98% (HPLC), lyophilized powder

• Formula empirica (notazione di Hill): C₁₅₈H₂₅₆N₅₂O₄₈S₁₁
• Numero CAS: 163515-35-3
• Peso molecolare: 4004.76
• UNSPSC Code: 12352200
• NACRES: NA.77
• MDL number: MFCD00239920
• Assay: ≥98% (HPLC)
• Form: lyophilized powder

Proprietà

• recombinant: expressed in E. coli
• Quality Segment: 100
• assay: ≥98% (HPLC)
• form: lyophilized powder
• solubility: aqueous buffer: soluble
• storage temp.: −20°C
• SMILES string: S1SC[C@@H]2NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H]3NC(=O)[C@H]4NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@
• InChI: 1S/C158H249N53O47S11/c1-77(2)55-96-138(241)205-105(144(247)186-86(125(165)228)28-18-47-173-156(166)167)70-264-262-68-103-131(234)177-63-115(217)176-64-116(218)183-87(25-12-15-44-159)128(231)178-65-117(219)184-88(29-19-48-174-157(168)169)129(232)179-66-118(220)185-89(26-13-16-45-160)133(236)202-107-72-267-269-75-110-149(252)195-98(56-81-23-10-9-11-24-81)143(246)208-124(80(5)213)154(257)209-123(79(4)212)153(256)199-102(61-122(226)227)141(244)196-99(58-83-62-172-76-181-83)139(242)189-92(37-39-113(163)215)136(239)190-94(42-53-260-7)132(235)182-78(3)126(229)187-91(30-20-49-175-158(170)171)134(237)188-90(27-14-17-46-161)135(238)203-108(73-266-265-71-106(146(249)193-96)204-137(240)93(38-40-114(164)216)191-151(254)111-31-21-50-210(111)119(221)67-180-130(233)97(194-147(107)250)57-82-33-35-84(214)36-34-82)148(251)198-100(59-120(222)223)140(243)197-101(60-121(224)225)142(245)206-109(150(253)201-103)74-268-263-69-104(200-127(230)85(162)41-52-259-6)145(248)192-95(43-54-261-8)155(258)211-51-22-32-112(211)152(255)207-110/h9-11,23-24,33-36,62,76-80,85-112,123-124,212-214H,12-22,25-32,37-61,63-75,159-162H2,1-8H3,(H2,163,215)(H2,164,216)(H2,165,228)(H,172,181)(H,176,217)(H,177,234)(H,178,231)(H,179,232)(H,180,233)(H,182,235)(H,183,218)(H,184,219)(H,185,220)(H,186,247)(H,187,229)(H,188,237)(H,189,242)(H,190,239)(H,191,254)(H,192,248)(H,193,249)(H,194,250)(H,195,252)(H,196,244)(H,197,243)(H,198,251)(H,199,256)(H,200,230)(H,201,253)(H,202,236)(H,203,238)(H,204,240)(H,205,241)(H,206,245)(H,207,255)(H,208,246)(H,209,257)(H,222,223)(H,224,225)(H,226,227)(H4,166,167,173)(H4,168,169,174)(H4,170,171,175)/t78-,79+,80+,85-,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,107-,108-,109-,110-,111-,112-,123-,124-/m0/s1
• InChI key: QPAKKWCQMHUHNI-GQIQPHNSSA-N

Descrizione

Biochem/physiol Actions

Chlorotoxin (CLTX) is a peptide isolated from the venom of scorpion Leiurus quinquestriatus.[1] It comprises three lysines at the N-terminal region and four disulfide bonds.[2] It can traverse the blood-brain barrier and can associate specifically with cancer cells especially in neuroblastoma, glioma, and medulloblastoma.[2] CLTX binds to chloride-gated channels (CLC30) and the matrix metalloproteinase-2 (MMP2) in glioma cells.[1] It is exploited in the imaging probe preparations for aiding non-cancer and cancer cell differentiation.[3]

Potent blocker of small-conductance Cl^- channels.

Features and Benefits

This compound is featured on the Chloride Channels page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

Informazioni sulla sicurezza

• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: Eyeshields, Gloves, type N95 (US)