α-Cyano-4-hydroxycinnamic acid (α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA) is soluble in methanol (up to 50 mg/ml). It is also soluble at 10 mg/ml using 50% acetonitrile in 0.05% TFA for MALDI-MS. The acetonitrile concentration can be adjusted for individual preferences.For biological applications, it has been solubilized at 100 mM in DMSO or 50 mM in ethanol.
C2020
α-Cyano-4-hydroxycinnamic acid
≥98% (TLC), powder, monocarboxylic acid transport inhibitor
Sinonimo/i:
α-CCA, α-CHCA, α-Cyano, 4-HCCA, ACCA
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10 G
CHF 75.00
25 G
CHF 172.00
Informazioni su questo articolo
Formula condensata:
HOC6H4CH=C(CN)CO2H
Numero CAS:
Peso molecolare:
189.17
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352106
EC Number:
248-879-1
MDL number:
Beilstein/REAXYS Number:
3271427
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α-Cyano-4-hydroxycinnamic acid, ≥98% (TLC), powder
InChI key
AFVLVVWMAFSXCK-VMPITWQZSA-N
InChI
1S/C10H7NO3/c11-6-8(10(13)14)5-7-1-3-9(12)4-2-7/h1-5,12H,(H,13,14)/b8-5+
SMILES string
OC(=O)\C(=C\c1ccc(O)cc1)C#N
assay
≥98% (TLC)
form
powder
color
yellow
Quality Level
mp
245-250 °C (lit.)
solubility
H2O: slightly soluble, methanol: water: soluble, polar organic solvents: soluble
storage temp.
2-8°C
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Categorie correlate
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Questo articolo | |||
|---|---|---|---|
| form powder | form powder | form powder | form solid |
| assay ≥98% (TLC) | assay - | assay 97% | assay - |
| Quality Level 300 | Quality Level 500 | Quality Level 100 | Quality Level 100 |
| storage temp. 2-8°C | storage temp. room temp | storage temp. 2-8°C | storage temp. 2-8°C |
| solubility H2O: slightly soluble, polar organic solvents: soluble, methanol: water: soluble | solubility - | solubility methanol: soluble 50 mg/mL, clear to slightly hazy, light yellow to yellow | solubility methanol: 10 mg/mL, clear |
| color yellow | color - | color - | color - |
Application
α-Cyano-4-hydroxycinnamic acid is a useful hydrophobic matrix solution for matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry.[3] Antibiotics, peptide nucleic acids (a new class of DNA mimics), and proteins with masses as high as 66,000 Da have been successfully analyzed by using this as a matrix solution.
signalword
Warning
hcodes
Hazard Classifications
Skin Sens. 1B
Classe di stoccaggio
11 - Combustible Solids
wgk
WGK 3
flash_point_f
Not applicable
flash_point_c
Not applicable
ppe
dust mask type N95 (US), Eyeshields, Gloves
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ZipTip® micro-SPE pipette tips are used as a single-step desalting, concentration, and purification tool for complex samples before mass spec analyses.
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