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B7283

Benserazide hydrochloride

≥98% (HPLC), solid, L-aromatic amino acid decarboxylase inhibitor

Sinonimo/i:

DL-Serine 2-(2,3,4-trihydroxybenzyl)hydrazide hydrochloride

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1 g
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CHF 133.00
5 g
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CHF 415.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C10H15N3O5 · HCl
Numero CAS:
Peso molecolare:
293.70
NACRES:
NA.77
PubChem Substance ID:
UNSPSC Code:
12352125
EC Number:
238-991-9
MDL number:
Assay:
≥98% (HPLC)
Form:
solid

CHF 133.00


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Nome del prodotto

Benserazide hydrochloride, ≥98% (HPLC), solid

biological source

synthetic

Quality Segment

assay

≥98% (HPLC)

form

solid

solubility

H2O: 10 mg/mL

originator

Roche

storage temp.

room temp

SMILES string

Cl.NC(CO)C(=O)NNCc1ccc(O)c(O)c1O

InChI

1S/C10H15N3O5.ClH/c11-6(4-14)10(18)13-12-3-5-1-2-7(15)9(17)8(5)16;/h1-2,6,12,14-17H,3-4,11H2,(H,13,18);1H

InChI key

ULFCBIUXQQYDEI-UHFFFAOYSA-N

Gene Information

human ... DDC(1644)

General description

Benserazide is a peripheral decarboxylase inhibitor.

Application

Benserazide has been used:
  • to inhibit dopa-decarboxylase
  • to induce dyskinesia
  • to test on purified bacterial TDCs to assess the extent to which it could affect bacterial decarboxylases
  • as a peripheral dopa decarboxylase inhibitor to treat mice

Biochem/physiol Actions

Inhibitor of L-aromatic amino acid decarboxylase.
Benserazide can block HK2 enzymatic activity in vitro. It is used along with levodopa to treat Parkinson′s disease.

Features and Benefits

This compound is a featured product for Neuroscience research. Click here to discover more featured Neuroscience products. Learn more about bioactive small molecules for other areas of research at sigma.com/discover-bsm.
This compound was developed by Roche. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

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Questo articolo
BP685B0477000B4563
Benserazide hydrochloride British Pharmacopoeia (BP) Reference Standard

BP685

Benserazide hydrochloride

Benserazide hydrochloride European Pharmacopoeia (EP) Reference Standard

B0477000

Benserazide hydrochloride

description

≥98% (HPLC), solid

description

British Pharmacopoeia (BP) Reference Standard

description

European Pharmacopoeia (EP) Reference Standard

description

≥98% (HPLC)

form

solid

form

solid

form

-

form

solid

assay

≥98% (HPLC)

assay

-

assay

-

assay

≥98% (HPLC)

Quality Level

100

Quality Level

-

Quality Level

-

Quality Level

100

storage temp.

room temp

storage temp.

2-8°C

storage temp.

-

storage temp.

room temp

solubility

H2O: 10 mg/mL

solubility

-

solubility

-

solubility

deionized water: 8 mg/mL

originator

Roche

originator

-

originator

-

originator

-


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Pittogrammi

Exclamation mark

Parola di avvertenza

Warning

Codici di pericolo

Hazard Classifications

Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Classe di stoccaggio

11 - Combustible Solids

Che succede?

WGK 2

Punto di infiammabilità (°F)

Not applicable

Punto di infiammabilità (°C)

Not applicable

DPI (dispositivi di protezione individuale)

dust mask type N95 (US), Eyeshields, Gloves



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Questions

  1. What is the recommended storage temperature for Benserazide hydrochloride (Product B7283) after the drug is suspended in water?

    1 answer
    1. Benserazide hydrochloride is soluble in water and should be dissolved in oxygen-free boiled water containing 0.1% sodium metabisulfite or other antioxidants. The solutions decompose on exposure to light and air. Benserazide HCl is a tan, photosensitive solid and should be stored tightly sealed at -4°C, protected from exposure to light. It is not recommended to store the aqueous solution for more than one day.

      Additionally, the product is subject to oxidation, and it is advisable to make solutions fresh daily. The product should be stored, as supplied, at room temperature for up to 1 year, and it should be protected from light.

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