B6060

BVT.948

≥98% (HPLC), solid

• Sinonimo/i: 4-Hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione
• Formula empirica (notazione di Hill): C₁₄H₁₁NO₃
• Numero CAS: 39674-97-0
• Peso molecolare: 241.24
• NACRES: NA.77
• PubChem Substance ID: 24724422
• UNSPSC Code: 12352200
• MDL number: MFCD00616487
• Assay: ≥98% (HPLC)
• Form: solid
• Quality level: 100
• Storage condition: desiccated, protect from light, under inert gas

Proprietà

• InChI: 1S/C14H11NO3/c1-14(2)9-10(15-13(14)18)7-5-3-4-6-8(7)11(16)12(9)17/h3-6,17H,1-2H3
• SMILES string: CC1(C)C(=O)N=C2c3ccccc3C(=O)C(O)=C12
• InChI key: BAQXWJQSUXZVIP-UHFFFAOYSA-N
• assay: ≥98% (HPLC)
• form: solid
• storage condition: desiccated, protect from light, under inert gas
• color: red
• solubility: DMSO: 18 mg/mL, H₂O: insoluble
• storage temp.: −20°C
• Quality Level: 100

Descrizione

Biochem/physiol Actions

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro.

Features and Benefits

BVT.948 is a non-competitive inhibitor of protein tyrosine phosphatase (PTP). Enhances insulin signaling in cells and inhibits several cytochrome P450 isoforms in vitro. Works through a different mechanism then the other PTP inhibitors. BVT.948 was able to enhance insulin signaling in cells, although it did not increase tyrosine phosphorylation globally. Furthermore, the compound was active in vivo, enhancing insulin tolerance tests in ob/ob mice, therefore apparently enhancing insulin sensitivity. BVT.948 was able to inhibit several other PTPs tested and also was efficient at inhibiting several cytochrome P450 isoforms in vitro.

Informazioni sulla sicurezza

• pictograms: GHS07
• signalword: Warning
• hcodes: H317
• pcodes: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• Hazard Classifications: Skin Sens. 1
• Classe di stoccaggio: 11 - Combustible Solids
• wgk: WGK 3
• flash_point_f: Not applicable
• flash_point_c: Not applicable
• ppe: dust mask type N95 (US), Eyeshields, Faceshields, Gloves