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AV40528

Sigma-Aldrich

Anti-SFRS10 (AB1) antibody produced in rabbit

IgG fraction of antiserum

Sinonimo/i:

Anti-Splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila)

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About This Item

Codice UNSPSC:
12352203

Origine biologica

rabbit

Coniugato

unconjugated

Forma dell’anticorpo

IgG fraction of antiserum

Tipo di anticorpo

primary antibodies

Clone

polyclonal

Forma fisica

lyophilized powder

PM

32 kDa

Reattività contro le specie

canine, rat, human, rabbit, horse, mouse, pig, bovine

Concentrazione

0.5 mg - 1 mg/mL

tecniche

immunohistochemistry: suitable
western blot: suitable

N° accesso NCBI

NP_004584

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... SFRS10(6434)

Descrizione generale

Transformer-2 protein homolog β/splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) (TRA2B, SFRS10) is an alternative splicing regulator that itself exists as alternative splice variants. Alternative mRNA splicing provides transcript diversity. SFRS10 binds SMN1/SMN2 RNA and restores full-length (FL)-SMN2 mRNA levels in vitro. Deficiency of SFRS10 results in early embryonic lethality.

Specificità

Anti-SFRS10 (AB1) polyclonal antibody reacts with canine, chicken, human, mouse, rat, pig, and bovine transformer-2 protein homolog β/splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) proteins.

Immunogeno

The immunogen for anti-SFRS10 antibody: synthetic peptide derected towards the N terminal of human SFRS10

Applicazioni

Anti-SFRS10 (AB1) polyclonal antibody is used to tag transformer-2 protein homolog β/splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) for detection and quantitation by Western blotting and in plasma by immunohistochemical (IHC) techniques. It is used as a probe to determine the roles of transformer-2 protein homolog β/splicing factor, arginine/serine-rich 10 (transformer 2 homolog, Drosophila) in the regulation of alternative pre-mRNA splicing.

Sequenza

Synthetic peptide located within the following region: MSDSGEQNYGERESRSASRSGSAHGSGKSARHTPARSRSKEDSRRSRSKS

Stato fisico

Lyophilized from PBS buffer with 2% sucrose

Esclusione di responsabilità

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Codice della classe di stoccaggio

12 - Non Combustible Liquids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

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The dorsal Lateral Geniculate Nucleus (dLGN) is the primary image-forming target of the retina and shares a reciprocal connection with primary visual cortex (V1). Previous studies showed that corticothalamic input is essential for the development of thalamocortical projections, but less
Devi Krishna Priya Karunakaran et al.
Gene expression patterns : GEP, 13(8), 425-436 (2013-08-13)
Processing of mRNAs including, alternative splicing (AS), mRNA transport and translation regulation are crucial to eukaryotic gene expression. For example, >90% of the genes in the human genome are known to undergo alternative splicing thereby expanding the proteome production capacity
Thomas C Whisenant et al.
PloS one, 10(12), e0144409-e0144409 (2015-12-08)
Activation of CD4 T cells is a reaction to challenges such as microbial pathogens, cancer and toxins that defines adaptive immune responses. The roles of T cell receptor crosslinking, intracellular signaling, and transcription factor activation are well described, but the
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eLife, 5 (2016-11-25)
Polypyrimidine-tract binding protein PTBP1 can repress splicing during the exon definition phase of spliceosome assembly, but the assembly steps leading to an exon definition complex (EDC) and how PTBP1 might modulate them are not clear. We found that PTBP1 binding

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