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A4941

Sigma-Aldrich

Activin A human

≥95% (SDS-PAGE), recombinant, expressed in baculovirus infected insect cells, lyophilized powder, suitable for cell culture

Sinonimo/i:

Activin A Protein, Growth Factor, Human Growth Factor

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About This Item

Numero CE:
201-069-1
Numero MDL:
MFCD02685750
Codice UNSPSC:
12352202
NACRES:
NA.32

Origine biologica

human

Livello qualitativo

200

Ricombinante

expressed in baculovirus infected insect cells

Saggio

≥95% (SDS-PAGE)

Forma fisica

lyophilized powder

Potenza

1-10 ng/mL ED50

PM

dimer 26 kDa (containing 116 amino acid residues βA subunits)

Confezionamento

pkg of 10 μg
pkg of 5 μg

tecniche

cell culture | mammalian: suitable

Impurezze

endotoxin, tested

N° accesso UniProt

P08476

Temperatura di conservazione

−20°C

Informazioni sul gene

human ... INHBA(3624)

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Descrizione generale

Activin A gene with two exons is mapped to human chromosome 2q35. Activin A also known as inhibin α-subunit belongs to the TGF-β (transforming growth factor-β) superfamily of proteins and its expression is exclusive to gonads, placenta and adrenal cortex.

Applicazioni

Activin A human has been used as a constituent of modified barth′s saline used in in vitro induction of pronephros. It has also been used as a constituent of Roswell Park memorial institute (RPMI) media to induce pancreatic differentiation of multipotent dermal fibroblasts in vitro.

Azioni biochim/fisiol

Activins play a vital role in the regulation of hormonogenesis, cellular homeostasis and differentiation programs. Elevated expression of activin A and B leads to the loss of muscle mass. Both activin A and B have a potential to act as a serum markers of chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME).

Stato fisico

Lyophilized from 0.2 μm filtered solution in 10 mM sodium citrate, pH 3.0.

Risultati analitici

The biological activity is determined by its ability to inhibit the proliferation of mouse MPC-11 cells.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H319,H335

Classi di pericolo

Eye Irrit. 2 - STOT SE 3

Organi bersaglio

Respiratory system

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 1

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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Differentiation of human multipotent dermal fibroblasts into islet-like cell clusters
Bi D, et al.
BMC Cell Biology, 11, 1-7 (2010)
Inhibin Alpha-Subunit (INHA) Expression in Adrenocortical Cancer Is Linked to Genetic and Epigenetic INHA Promoter Variation
Hofland J, et al.
PLoS ONE, 9, e104944-e104944 (2014)
Activin B is a novel biomarker for chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) diagnosis: a cross sectional study
Lidbury BA, et al.
Journal of Translational Medicine, 15 (2017)
T K Woodruff
Biochemical pharmacology, 55(7), 953-963 (1998-05-30)
Activin is an important molecule that regulates hormonogenesis, cellular homeostasis (divide or die pathways), and differentiation programs (developmentally and in adult cells). The cellular mechanisms that integrate an activin signal into a physiological response include a binary receptor complex and
Valérie Bello et al.
Developmental biology, 317(1), 106-120 (2008-04-02)
Dystroglycan (Dg) is a laminin receptor that is expressed at the interface between the basement membrane and the cell membrane. Dg has been reported to play a role in skeletal muscle cell stability, morphogenesis of neuroepithelial tissues, and in regulating
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