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A4660

Sigma-Aldrich

6-Thioguanine

Hybri-Max™, 50 ×, γ-irradiated, lyophilized powder, BioXtra, suitable for hybridoma

Sinonimo/i:

2-Amino-6-mercaptopurine, 2-Amino-6-purinethiol

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2.5 MG
CHF 53.40

CHF 53.40

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2.5 MG
CHF 53.40

About This Item

Formula empirica (notazione di Hill):
C5H5N5S
Numero CAS:
154-42-7
Peso molecolare:
167.19
Beilstein:
157765
Numero CE:
205-827-2
Numero MDL:
MFCD00233553
Codice UNSPSC:
12352207
ID PubChem:
24890892
NACRES:
NA.75

CHF 53.40

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Origine biologica

synthetic (organic)

Livello qualitativo

200

Grado

Hybri-Max™

Sterilità

γ-irradiated

Nome Commerciale

BioXtra

Saggio

~98%

Stato

lyophilized powder

Concentrazione

50 ×

tecniche

cell culture | hybridoma: suitable

Impurezze

endotoxin, tested

Punto di fusione

≥300 °C (lit.)

Solubilità

1 M NaOH: 50 mg/mL, clear to slightly hazy

Temperatura di conservazione

room temp

Stringa SMILE

NC1=Nc2nc[nH]c2C(=S)N1

InChI

1S/C5H5N5S/c6-5-9-3-2(4(11)10-5)7-1-8-3/h1H,(H4,6,7,8,9,10,11)
WYWHKKSPHMUBEB-UHFFFAOYSA-N

Informazioni sul gene

human ... IMPDH1(3614) , IMPDH2(3615)

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Categorie correlate

Applicazioni

Used in hybridoma formation applications as a selection agent.

Azioni biochim/fisiol

Ribosylated and phosphorylated by the same pathway as natural purine bases; as the nucleotide, inhibits a variety of cellular processes involved in nucleic acid synthesis. Has a long history as an effective treatment of leukemia.

Ricostituzione

Reconstitute contents of vial with 10 ml sterile cell culture medium. Stock solution is sufficient to prepare 500 ml medium. Final working concentration: 30 μM 2-amino-6-mercaptopurine.

Note legali

Hybri-Max is a trademark of Sigma-Aldrich Co. LLC

Pittogrammi

Skull and crossbones
GHS06

Avvertenze

Danger

Indicazioni di pericolo

H301

Consigli di prudenza

P301 + P310

Classi di pericolo

Acute Tox. 3 Oral

Codice della classe di stoccaggio

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

Eyeshields, Faceshields, Gloves, type P2 (EN 143) respirator cartridges

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Certificati d'analisi (COA)

Lot/Batch Number
0000333273
0000339114
0000330913
0000311389
0000299468

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Donghui Li et al.
Nucleic acids research, 49(5), 2642-2654 (2021-02-17)
The CRISPR/Cas9 system is a technology for genome engineering, which has been applied to indel mutations in genes as well as targeted gene deletion and replacement. Here, we describe paired gRNA deletions along the PIGA locus on the human X
N K H de Boer et al.
Digestion, 73(1), 25-31 (2006-02-24)
Recently, the suggestion to use 6-thioguanine (6-TG) as an alternative thiopurine in patients with inflammatory bowel disease (IBD) has been discarded due to reports about possible (hepato) toxicity. During meetings arranged in Vienna and Prague in 2004, European experts applying
Quentin Gueranger et al.
The Journal of investigative dermatology, 134(5), 1408-1417 (2013-11-29)
Damage to skin DNA by solar UV is largely unavoidable, and an optimal cellular response to it requires the coordinated operation of proteins in numerous pathways. A fully functional DNA repair proteome for removing harmful DNA lesions is a prerequisite
Reto Brem et al.
Cancer research, 72(18), 4787-4795 (2012-07-24)
The thiopurines azathioprine and 6-mercaptopurine have been extensively prescribed as immunosuppressant and anticancer agents for several decades. A third member of the thiopurine family, 6-thioguanine (6-TG), has been used less widely. Although known to be partly dependent on DNA mismatch
Valentin Ruillier et al.
JCI insight, 5(4) (2020-01-29)
Lesch-Nyhan disease (LND) is a rare monogenic disease caused by deficiency of the salvage pathway enzyme hypoxanthine-guanine phosphoribosyltransferase (HGPRT). LND is characterized by severe neuropsychiatric symptoms that currently cannot be treated. Predictive in vivo models are lacking for screening and
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