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A4377

S-(5′-Adenosyl)-L-methionine iodide

≥80% (spectrophotometric assay), suitable for cell culture

Sinonimo/i:

AdoMet, SAM

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Cambia visualizzazione
Voi/SKUDisponibilitàPrezzo
5 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 178.00
25 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 483.00
100 mg
Per conoscere la disponibilità, visualizza il carrello
CHF 1620.00

Informazioni su questo articolo

Formula empirica (notazione di Hill):
C15H23IN6O5S
Numero CAS:
Peso molecolare:
526.35
NACRES:
NA.26
PubChem Substance ID:
UNSPSC Code:
12352209
EC Number:
222-486-5
MDL number:
Beilstein/REAXYS Number:
4120787

CHF 178.00


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Nome del prodotto

S-(5′-Adenosyl)-L-methionine iodide, ≥80% (HPLC), ≥80% (spectrophotometric assay)

Quality Segment

assay

≥80% (HPLC), ≥80% (spectrophotometric assay)

form

powder

technique(s)

cell culture | mammalian: suitable

color

white to off-white

solubility

H2O: 100 mg/mL

shipped in

dry ice

storage temp.

−20°C

SMILES string

[I-].C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)n2cnc3c(N)ncnc23

InChI

1S/C15H22N6O5S.HI/c1-27(3-2-7(16)15(24)25)4-8-10(22)11(23)14(26-8)21-6-20-9-12(17)18-5-19-13(9)21;/h5-8,10-11,14,22-23H,2-4,16H2,1H3,(H2-,17,18,19,24,25);1H/t7-,8+,10+,11+,14+,27?;/m0./s1

InChI key

XQMWYLXPEGFCFT-XKGORWRGSA-N

Application

S-(5′-Adenosyl)-L-methionine (SAM, AdoMet) is used as a primary methyl donor molecule in mammalian cell culture and the first step metabolite in methionine biosynthesis.

Biochem/physiol Actions

Methyl donor; cofactor for enzyme-catalyzed methylations, including catechol O-methyltransferase (COMT) and DNA methyltransferases (DNMT). Although present in all cells, it is concentrated in liver where 85% of all methylation reactions occur. It is also involved in regulating liver function, growth, and response to injury.

Analysis Note

Purity based on UV and HPLC.

Disclaimer

This material is very unstable at room temperature.

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Questo articolo
A2408A7007N6760
description

≥80% (HPLC), ≥80% (spectrophotometric assay)

description

≥80% (HPLC), ≥80% (spectrophotometric assay)

description

≥75%

description

With L-glutamine, without sodium bicarbonate, powder, suitable for cell culture

form

powder

form

powder

form

powder

form

powder

technique(s)

cell culture | mammalian: suitable

technique(s)

-

technique(s)

-

technique(s)

cell culture | mammalian: suitable

assay

≥80% (spectrophotometric assay), ≥80% (HPLC)

assay

≥80% (spectrophotometric assay), ≥80% (HPLC)

assay

≥75%

assay

-

storage temp.

−20°C

storage temp.

−20°C

storage temp.

−20°C

storage temp.

2-8°C

solubility

H2O: 100 mg/mL

solubility

H2O: 100 mg/mL

solubility

H2O: 100 mg/mL

solubility

-

color

white to off-white

color

white to off-white

color

white to off-white

color

-


Pittogrammi

Exclamation mark

Parola di avvertenza

Warning

Codici di pericolo

Hazard Classifications

Skin Sens. 1

Classe di stoccaggio

11 - Combustible Solids

Che succede?

WGK 3

Punto di infiammabilità (°F)

Not applicable

Punto di infiammabilità (°C)

Not applicable

DPI (dispositivi di protezione individuale)

Eyeshields, Faceshields, Gloves, type N95 (US)



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Certificati d'analisi (COA)

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Questions

1–3 of 3 Questions  
  1. How can I determine the shelf life / expiration / retest date of this product?

    1 answer
    1. If this product has an expiration or retest date, it will be shown on the Certificate of Analysis (COA, CofA). If there is no retest or expiration date listed on the product's COA, we do not have suitable stability data to determine a shelf life. For these products, the only date on the COA will be the release date; a retest, expiration, or use-by-date will not be displayed.
      For all products, we recommend handling per defined conditions as printed in our product literature and website product descriptions. We recommend that products should be routinely inspected by customers to ensure they perform as expected.
      For products without retest or expiration dates, our standard warranty of 1 year from the date of shipment is applicable.
      For more information, please refer to the Product Dating Information document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/418/501/product-dating-information-06-25-mk.pdf

      Helpful?

  2. We are looking for one carbon metabolites in our serum samples, SAM is one of them. In our lab, we have S-(5′-Adenosyl)-L-methionine iodide (A4377). Can this chemical be used as one of the standards for the derivatisation-based GC-MS analysis?

    1 answer
    1. This product is not a standard and has not been tested for suitability for GC derivatization. Unfortunately, there is no SAM standard available in the product catalog.

      Helpful?

  3. How is shipping temperature determined? And how is it related to the product storage temperature?

    1 answer
    1. Products may be shipped at a different temperature than the recommended long-term storage temperature. If the product quality is sensitive to short-term exposure to conditions other than the recommended long-term storage, it will be shipped on wet or dry-ice. If the product quality is NOT affected by short-term exposure to conditions other than the recommended long-term storage, it will be shipped at ambient temperature. As shipping routes are configured for minimum transit times, shipping at ambient temperature helps control shipping costs for our customers. For more information, please refer to the Storage and Transport Conditions document: https://www.sigmaaldrich.com/deepweb/assets/sigmaaldrich/marketing/global/documents/316/622/storage-transport-conditions-mk.pdf

      Helpful?

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