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Merck
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Documenti

A2731

Sigma-Aldrich

AMG 9810

≥98% (HPLC), powder

Sinonimo/i:

2E-N-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-[4-(1,1-dimethylethyl)phenyl]-2-Propenamide

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About This Item

Formula empirica (notazione di Hill):
C21H23NO3
Numero CAS:
545395-94-6
Peso molecolare:
337.41
Numero MDL:
MFCD00955103
Codice UNSPSC:
12352203
ID PubChem:
329770793
NACRES:
NA.77

Livello qualitativo

100

Saggio

≥98% (HPLC)

Forma fisica

powder

Colore

white to beige

Solubilità

DMSO: >5 mg/mL

Ideatore

Amgen

Temperatura di conservazione

2-8°C

Stringa SMILE

CC(C)(C)c1ccc(\C=C\C(=O)Nc2ccc3OCCOc3c2)cc1

InChI

1S/C21H23NO3/c1-21(2,3)16-7-4-15(5-8-16)6-11-20(23)22-17-9-10-18-19(14-17)25-13-12-24-18/h4-11,14H,12-13H2,1-3H3,(H,22,23)/b11-6+
GZTFUVZVLYUPRG-IZZDOVSWSA-N

Azioni biochim/fisiol

AMG 9810 is the cinnamide TRPV1 (vanilloid receptor 1) antagonist, that can prevent eye wiping behavior, stimulated by capsaicin and can inverse hyperalgesia in an animal model of inflammatory pain. It possesses antihyperalgesic properties.
AMG 9810 is a potent, non-vanilloid, antagonist of the TRPV1 receptor. IC50 = 17 nM.

Caratteristiche e vantaggi

This compound was developed by Amgen. To browse the list of other pharma-developed compounds and Approved Drugs/Drug Candidates, click here.

Pittogrammi

Exclamation mark
GHS07

Avvertenze

Warning

Indicazioni di pericolo

H302,H413

Classi di pericolo

Acute Tox. 4 Oral - Aquatic Chronic 4

Codice della classe di stoccaggio

11 - Combustible Solids

Classe di pericolosità dell'acqua (WGK)

WGK 3

Punto d’infiammabilità (°F)

Not applicable

Punto d’infiammabilità (°C)

Not applicable

Dispositivi di protezione individuale

dust mask type N95 (US), Eyeshields, Gloves

Certificati d'analisi (COA)

Cerca il Certificati d'analisi (COA) digitando il numero di lotto/batch corrispondente. I numeri di lotto o di batch sono stampati sull'etichetta dei prodotti dopo la parola ‘Lotto’ o ‘Batch’.

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GSK1016790A ≥98% (HPLC)

Sigma-Aldrich

G0798

GSK1016790A

BAPTA-AM ≥95% (HPLC)

Sigma-Aldrich

A1076

BAPTA-AM

GW9662 >98% (HPLC)

Sigma-Aldrich

M6191

GW9662

Capsaicin ≥95%, from Capsicum sp.

Sigma-Aldrich

M2028

Capsaicin

Michele Hummel et al.
World journal of gastroenterology, 23(33), 6065-6076 (2017-10-04)
To evaluate whether non-steroidal anti-inflammatory drugs (NSAIDs)-induced gastropathy is a clinically predictive model of referred visceral hypersensitivity. Gastric ulcer pain was induced by the oral administration of indomethacin to male, CD1 mice ( Results showed that two opioids and a
Mark H Pitcher et al.
Molecular pain, 3, 17-17 (2007-07-03)
The Na+, K+, 2Cl- type I cotransporter (NKCC1) and TRPV1 receptors, at the level of the dorsal horn, have been implicated in mediating allodynia in response to an inflammatory insult. The NKCC1 cotransporter regulates intracellular [Cl-] and thus the magnitude
Elham Hakimizadeh et al.
Iranian journal of basic medical sciences, 15(3), 795-802 (2013-03-16)
Fatty acid is amide hydrolase which reduce endogenous anandamide. Transient receptor potential vanilloid-1 (TRPV1) channels have been reported to have a role in the modulation of anxiety-like behaviors in rodents. In the present study, the effects of either endocannabinoid system
Éva Borbély et al.
Frontiers in pharmacology, 11, 594479-594479 (2021-02-02)
The tachykinin hemokinin-1 (HK-1) is involved in immune cell development and inflammation, but little is known about its function in pain. It acts through the NK1 tachykinin receptor, but several effects are mediated by a yet unidentified target. Therefore, we
AMG 9810 [(E)-3-(4-t-butylphenyl)-N-(2, 3-dihydrobenzo [b][1, 4] dioxin-6-yl) acrylamide], a novel vanilloid receptor 1 (TRPV1) antagonist with antihyperalgesic properties
Gavva N R, et al.
Journal of Pharmacology and Experimental Therapeutics, 313(1), 474-484 (2005)
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